我国药用大黄居群地理变异及品质形成效应研究

The individuals of same species display geographic variation under different environmental conditions to certain extent，and the geographic variation of the species that result from geographical differences of the communities reflect the evolution ways and adapting strategies of the communities under different habitat conditions．The "Chinese pharmacopoeia " in 2010 version has been loaded with three medicinal material source， Rheum officinale is one of the species.Compared the other two species,Rheum officinale geographical distribution range is broader , hereditary background is complicated , as well as destructive mining, high-quality rhubarb resources are gradually short-supplied..Therefore,depended on the full investigation of Rheum officinale different populations,this project will systemly research the character variation, chemical variation, genetic variation etc. Revealed Rheum officinale geographical variation pattern and the law.Simultaneously, this project also will collect ecological environmental data of different area, extract the dominant factor from quality forms of Rheum officinal, Studying on the relations between geographic variation and quality formation to Rheum officinale, studying on the effection of environmental modification that genetic variation caused by geographic variation.Finally,this study will elucidate the characteristics of Rheum officinal geographic variation , Constructive the geographical regionalization and spatial distribution about Rheum officinal quality formation based on geographic variation, provide a basis for Rheum officinal production layout, selection of improved varieties, resource protection ,clinical application and so on.

同一物种在不同的地理环境条件下会表现出一定的地理变异，这种由于地理差异而引起的居群间地理变异反映了物种对不同环境条件的进化方式和适应对策。药用大黄Rheum officinale Baill.作为《中国药典》2010年版收载的三个大黄药材来源品种之一，相比其它两个品种，地理分布更广，生态环境多样，地理变异明显，加之破坏性采挖，优质大黄资源日渐紧缺。本项目将采取居群学的方法，在对药用大黄各地理居群进行充分调查的基础上，对其性状变异、化学变异、遗传变异等进行系统研究，揭示药用大黄地理变异模式及规律。同时，采集各分布区域地理生态环境数据，提取影响药用大黄品质形成主导因子，研究药用大黄地理变异与品质形成的关系，以及地理变异对遗传因子的环境饰变效应。最终明确药用大黄地理变异特性，构建基于地理变异基础上的药用大黄品质形成空间分布地理区划，为药用大黄生产基地布局、良种选择、种质保护、临床应用等提供依据。

同一物种在不同的地理环境条件下会表现出一定的地理变异，这种由于地理差异而引起的居群间地理变异反映了物种对不同环境条件的进化方式和适应对策。药用大黄Rheum officinale Baill.作为《中国药典》2010 年版收载的三个大黄药材来源品种之一，相比其它两个品种，地理分布更广，生态环境多样，地理变异明显，加之破坏性采挖，优质大黄资源日渐紧缺。本项目采取居群学的方法，在对药用大黄各地理居群进行充分调查的基础上，对其性状变异、化学变异、遗传变异等进行系统研究，揭示药用大黄地理变异模式及规律。同时，采集各分布区域地理生态环境数据，提取影响药用大黄品质形成主导因子，研究药用大黄地理变异与品质形成的关系，以及地理变异对遗传因子的环境饰变效应。最终明确药用大黄地理变异特性，构建基于地理变异基础上的药用大黄品质形成地理区划，为药用大黄生产基地布局、良种选择、种质保护、临床应用等提供依据。