胚胎干细胞Ryanodine受体基因剔除对心肌细胞分化和功能影响
基本信息
结项摘要
Ryanodin受体（RyR）2是成年心肌肌浆网释放Ca(2+)的主要通道，在调控胞浆Ca(2+)和心肌功能中起着关键作用。本课题在鼠胚胎干细胞剔除RyR2基因的基础上，研究RyR2对心肌细胞分化发育的影响，阐明RyR2在发育早期心肌细胞兴奋收缩耦联中的地位，认识心肌RyR在G蛋白耦联受体信号转导通路中的调控，揭示RyR2对早期心肌细胞分化发育和功能调控的作用。
项目摘要
项目成果
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数据更新时间：2023-05-31
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