目前国内外煤工尘肺发病率仍然很高,在所有尘肺中居第二位,是主要职业病,其发病机制不明,由于缺少理想的动物模型,限制了煤工尘肺防治方法的研究。因此,本实验拟采用非暴露气管灌注法和气溶胶吸入法2种染尘方式建立大鼠煤工尘肺动物模型,通过一些特定的检测指标,确定一种更为合适的安全性高、重复性好、准确、经济、易于制造和评估的模型,对开展煤工尘肺防治方法研究具有重要意义。
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数据更新时间:2023-05-31
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