有序微孔材料制备及其药物负载和控释性能研究

It is suggested that Metal-organic frameworks (MOFs) can be used as non-toxic drug carriers with high loading capacity, slow releasing property and specifically targeted to diseased tissues, due to their structural and channels diversity, intrinsic biodegradability and versatile functionality. The approaches to preparation of low-toxic and ordered MOFs could be proposed by taking consideration of the properties of metal and the ligands, especially non-toxic or intrinsic materials of organism. The synthetic conditions of desired frameworks will be attempted and optimized, with the aim to establish the preparation methodology of MOFs. Our research has been focused on the increasement of drug loading and the controlment of releasing rate by exchanging of mobile counter ions. We are aiming to clarify the influence of geometry features of pores on the dynamic processing of drug loading and release, and further investigate the relationship between the structure of MOFs and the property of materials as drug carriers. Finally, we modify MOFs with targeted molecular to improve the efficiency of drug. This study will give a deeper insight to design and prepare MOFs that provide a platform for customer-defined properties and make MOFs possible to be used as excellent drug carriers in clinic applications. During this study, it is expected to own independent intellectual property rights in this field, publish over 8 SCI papers, apply 3-4 patents, and train 3-4 graduate students.

基于有序微孔金属-有机框架材料的孔隙率高、比表面积大、孔结构可调性和表面可修饰性强、生物可降解性好的特点，拟开展高载药量、易缓释且具有靶向性的无毒或低毒治疗药物载体的制备及其药物负载和控释性能研究。选择生物相容性好的金属离子和有机配体，探索无毒或低毒有序微孔金属-有机框架材料的合成条件、孔结构调控和表面修饰规律；利用离子型框架材料的离子交换作用提高治疗药物的装载量并调控缓释特性，研究药物释放动力学，探明离子型微孔框架材料与治疗药物装载、缓释的构效关系及其控制规律；通过对微孔框架材料表面进行靶向分子修饰赋予药物载体的靶向性，提高药物的特异性和有效性。项目研究将为生物相容有序微孔框架材料和基于此的多功能缓释药物载体材料的设计、制备和医学应用奠定理论和实验基础。通过项目的研究获得相关领域中的自主知识产权，发表SCI 收录论文8篇以上；申请发明专利3-4 项；培养研究生3-4名。

本项目基于有序微孔金属-有机框架材料的孔隙率高、比表面积大、孔结构可调性和表面可修饰性强、生物可降解性好的特点，开展了高载药量、易缓释和具有靶向性的无毒或低毒治疗药物载体的制备及其药物负载和控释性能研究。选择生物相容性好的金属离子和有机配体，探索了无毒或低毒有序微孔金属-有机框架材料的合成条件、孔结构调控和表面修饰规律；利用离子型框架材料的离子交换作用提高了治疗药物的装载量并调控缓释特性，研究药物释放动力学并探明了离子型微孔框架材料与治疗药物装载、缓释的构效关系及其控制规律；通过对微孔框架材料表面进行靶向分子修饰赋予药物载体的靶向性，提高了药物的特异性和有效性。项目研究为生物相容有序微孔框架材料和基于此的多功能缓释药物载体材料的设计、制备和医学应用奠定了理论和实验基础。通过项目的研究获得相关领域中的自主知识产权，发表SCI 收录论文13篇，获授权国家发明专利3 项，申请国家发明专利1项，培养博士研究生2名，硕士研究生多名。