高温热浪对心脑血管疾病的影响及其机制研究

Under the condition of global warming, heat waves occur more and more frequently, which have been turned out to be the hot topic of this century. The epidemiological studies have found that they can cause serious health issues, both including diseases and deathes. The purpose of this project is to analyze the relationship between cardiovascular disease(CVD) and heat wave by collecting the data of CVDs and meteorology,and also explore the related mechanism through the epidemiological investigation and animal experiments. The time series analysis will be used to explore the correlation between heat wave and CVD by gathering the meteorological data of heat wave and the clinical data of CVD in Shijiazhuang and Nanjing. Heat wave models,including dry and wet heat wave, will be established by analyzing the meteorological data.Sensitive risk factors related to CVD will be selected and determined in animals exposed to the heat waves.

在全球气候变暖的背景下，热浪发生越来越频繁，正越来越受到人们的关注。许多流行病学研究发现其能造成严重的健康事件，严重者包括死亡。本项目是通过收集兰州、南京两城市的心脑血管疾病资料和气温、湿度、风速等相关气象资料，利用时间序列分析热浪与心脑血管疾病的关系。根据两城市的热浪气象资料建立干热和湿热热浪模型，利用气象环境模拟箱模拟对动物的热刺激，并检测和分析心脑血管疾病有关危险因子。最后通过人群资料和动物实验来探讨诱发和加重心脑血管疾病的相关机制。

在全球气候变暖的背景下，热浪发生越来越频繁，正越来越受到人们的关注。许多流行病学研究发现其能造成严重的健康事件，严重者包括死亡。本项目是通过收集兰州、南京两城市的心脑血管疾病资料和气温、湿度、风速等相关气象资料，利用时间序列分析热浪与心脑血管疾病的关系。根据两城市的热浪气象资料建立干热和湿热热浪模型，利用气象环境模拟箱模拟对动物的热刺激，并检测和分析心脑血管疾病有关危险因子。 最后通过人群资料和动物实验来探讨诱发和加重心脑血管疾病的相关机制。