催化不对称串联反应合成手性3-取代黄烷酮类化合物的研究

3-Substituted chiral flavanones are privileged natural products that display a wide variety of biological activities. Much focus has been placed on flavanonols, in which the substitute at C3 is a hydroxyl, however, the reported syntheses usually need many steps and are not efficient. Because of this liability and the need for generating enantio-enriched 3-substituted flavanones, developing novel, highly stereoselective methods is very important. In this project, we try to exploit the asymmetric domino reactions, triggered by intramolecular oxa-Michael addition, to synthesis many diverse optical 3-substituted flavanones, which can be further used in organic synthesis and drug development.

手性3-取代黄烷酮是一类有广泛生物活性的化合物。有关研究主要集中在双氢黄烷醇上，其他3-取代手性黄烷酮还鲜有报道，且已有合成方法都存在路线冗长、操作繁琐、效率低等缺点。发展高效、高立体选择性、能提供结构多样的3-取代手性黄烷酮的合成方法具有重要意义。本项目拟实现由分子内oxa-Michael加成反应启动的不对称串联反应，从而为合成结构多样的光学活性3-取代黄烷酮类化合物建立新的方法，为这些化合物在有机合成和药物开发中的进一步应用奠定基础。