连续无创外周血管光声成像用于血管损伤/修复机制研究

Vascular injury and repair is of great significance to the precaution of cardiovascular disease. Continuously noninvasive vascular imaging is invaluable to the study of the mechanism of vascular injury and repair. Benefited from the capability of high imaging contrast, high resolution and large imaging depth, photoacoustic imaging is greatly suitable for the acquisition of key information of molecular markers closely linked with the mechanism of vascular injury and repair, as well as the morphology and functional information related to vasculopathy. Therefore it has high potential to be used as a revolutionary innovative imaging method for the study of the mechanism of vascular injury and repair. In this study, by taking full advantage of the novel multi-scale photoacoustic imaging technology and instruments developed in our lab, and selecting peripheral vessels as the representative site of vasculopathy, we aim to obtain molecular marker information as well as vascular morphology and functional information that are closely related to cardiovascular disease, based on which the correlation of these information and the corresponding mechanism can be studied. Further, we will also carry out the research by studying the variation of these information under the intervention of cardiovascular drugs. The goal of the study is to validate the performance of photoacoustic imaging for the study of the mechanism of vascular injury and repair, as well as to explore novel mechanisms regarding to the pathogenesis of cardiovascular disease.

血管损伤/修复机制研究对于心脑血管病防治具有重要意义。基于影像学技术手段的连续无创血管成像对于血管损伤/修复机制研究具有重要价值。光声成像得益于其高对比度、高分辨、大穿透深度等诸多优势，且能够在活体水平采用同一影像模式获取与血管损伤/修复机制密切相关的重要分子标志物信息，以及反映血管病变情况的形态、功能信息，有潜力为血管损伤/修复机制研究提供革新性技术手段和方法。本项目选取心脑血管病代表性病变部位暨外周血管进行研究，利用团队自主创新研发的跨尺度光声成像技术和仪器，连续无创获取心脑血管疾病潜在分子标志物与外周血管形态、功能信息，研究其相关性及内在机制；并结合心脑血管病治疗药物，研究药物干预情况下分子标志物及血管形态、功能信息的改变。在论证光声成像用于血管损伤/修复机制研究有效性的同时，也旨在揭示和发现心脑血管病发病的新机制与新原理。

血管损伤/修复机制研究对于心脑血管病防治具有重要意义。基于影像学技术手段的连续无创血管成像对于血管损伤/修复机制研究具有重要价值。光声成像能够在同一影像模式下获取与血管损伤/修复机制密切相关的重要分子标志物信息以及反应血管病变情况的形态功能信息，有潜力为血管损伤/修复机制研究提供革新性技术手段和方法。本研究选取了心脑血管病代表性病变部位暨外周血管进行研究，团队自主创新研发了多套跨尺度的光声成像技术和仪器，能够连续无创获取心脑血管疾病潜在分子标志物以及外周血管形态功能信息。结合心脑血管病治疗药物，还能够研究药物干预情况下分子标志物及血管形态功能信息的改变。研究结果证明了光声成像用于血管损伤/修复机制研究有效性的同时，也能够揭示和发现心脑血管病发病的机制机理。