纳米修饰与3D打印联用技术在医用材料中的应用

3D printing technology is capable to construct complex bionic structure precisely in a short time, and is thus ideal for personalized production of medical devices. However, at this stage, the available 3D printing biomedical raw materials are very limited, and their surface properties are also insufficient for the practical requirements. In 2009, the appliant proposed a reliable approach to modify complex structured substrate with high biocompatible inorganic nanoarrays, which is an ideal strategy for 3D printing technology. Herein, the appliant planed to start a joint research project between nano-modification and 3D printing. This joint technique is based on the actual needs of the common biomedical materials, especially artificial teeth and bone tissue materials. By modifying the surfaces of 3D printing products with intelligent nanomaterials, some key performance parameters of biomedical devices, such as biocompatibility, antibacterial activity and hydrophobic ability, can be significantly improved. Incorporated with original innovation and long-term development potential, this technology can fill in the domestic gap in the field of rapid manufacturing personalized intelligent biomedical nano-materials, and generate considerable economic benefits. The average impact factor of the appliant's first author selected publication is 8.2.He also owns 5 patents and 2 provincial awards, representing the leading level in domestic counterparts.

3D打印技术可在短时间内精确构筑复杂的仿生结构，非常适用于医用器件的个性化生产。然而，目前可实际应用的医用3D原料有限、且表面性能难以满足生物医用材料的实际使用需求。申请人于09年在国际上率先提出在复杂结构的基底表面，修饰高生物相容性无机纳米阵列的技术方案，非常适用于3D打印领域。现计划联合纳米修饰与3D打印两项前沿技术，通过在3D打印器件表面负载功能型纳米材料，显著提升成品的生物相容性、抗菌性、疏水能力等关键性能参数。重点研究该项联用技术在快速制备人造牙齿、人造骨骼等植入材料的应用价值。本项目具有原始创新性和长远发展前景，可填补我国在个性化生产纳米医用材料领域的空白，并产生可观的经济效益。申请人在相关领域申请专利5项，获省部级奖励两次，七篇代表性论文平均影响因子达8.2，在国内同行中位居前列。

在基金委的支持下，项目负责人及其课题组自2015年开始利用3D打印技术制作出充分匹配临床手术需求的植入材料，并通过表面修饰相功能型纳米材料赋予其长效抗菌性能。随后，还可在抗菌剂上负载可控释放的“开关”，使抗菌剂在有细菌感染时大量释放，从而有效提升抗菌效果，同时降低耐药性菌种产生的概率。相关论文已在ACS nano，Advanced Functional Materials，ACS Applied Materials & Interfaces，ACS Sustainable Chemistry & Engineering，Journal of Materials Chemistry B等国际权威期刊中发表，共发表论文28篇（仅统计第一作者或通讯作者论文），已发表论文平均影响因子达5.77。相关工作获2016年江西省自然科学奖二等奖。