以新型杯芳烃为主体的分子识别技术的基础研究和应用

Recently, the applications of novel calixarenes, the tertiary supramolecular compounds to molecular recognition technique have been highlighted in various fields. In this research project, series of novel calixarene compounds and their derovatoves, molecularly imprinted polymers have been synthesized and characterized. These novel compounds have been used to a number of techniques including ion-selective electrodes, piezoelectric crystal sensor, fluorescent probes, ion-sensitive field effect transistor sensor, liquid membrane transport, high performance liquid chromatograohy and solid-phase extraction etc., which have been applied in molecular recognition and separation for metal ions, biomolecules, chiral compounds, drugs as well as some others in complex systems. At the same time, the mechanism of host-guest interaction have been studies intensively with various theories. The fundamental studies contributes to obtaining the characteristic host molecules for the techniques of molecular recognition, separation and enrichment，which has potiental applications extensively. In addition, it also contributes significantly to the development of analytical chemistry to the direction integrating numerous knowledge, theories and techniques.

以第三代超分子—新型杯芳烃为主体的分子识别技术是近年来边缘学科的热点之一。通过该项目的研究，有助于实现从分子水平，设计不同的分子识别体系各种物质如从金属到生物活性分子进行识别富集和识别分析，有助于实现分析化学向多元学科，理论与技术相融合的方向发展。它有广阔的应用前景，能提供可信的分析方法和富集纯制物。..