基于氨基酸还原Schiff碱配体的多孔手性配位聚合物的合成与手性拆分性能研究

Porous chiral coordination polymers have very important potential applications in research areas such as asymmetric catalysis, chiral resolution, chiral recognition, information storage, non-linear optical and ferroelectric materials. In this research proposal, reduced Schiff base ligands based on natural (L)-α-amino acids and salicylaldehyde derivatives are employed for construction of porous chiral coordination polymers, and investigations on their chiral resolution properties will also be performed. The control over crystal structure will be achieved through ligand design and reaction condition control. It is expected that the chiral recognition mechanism of these coordination polymers will be revealed at the molecular level and the control over their chiral resolution properties will also be achieved. Additionally, the structure-property relationship will be established to obtain several universal chiral materials. The research results of this proposal will provide scientific support for the further development and application of chiral coordination polymers. At the end of this proposal, 5-7 SCI papers will be published on academic journals (2-4 of them will be published on high quality international jounals whose IF ＞ 3.0 ).

多孔手性配位聚合物在不对称催化、手性拆分、手性识别、信息存储、非线性光学材料和铁电材料等领域具有极其重要的应用价值。本项目提出以基于天然(L)-α-氨基酸-水杨醛衍生物的还原Schiff碱为配体构筑多孔手性配位聚合物并研究其手性拆分性能，通过对配体进行设计和控制反应条件等手段来调控手性配位聚合物的结构。预期目标将在分子水平上阐明手性配位聚合物的手性识别机制，实现对其手性拆分性能进行调控的目标，进而建立手性配位聚合物的构效关系模型并获得几种具有一定普适性的手性材料。项目的研究成果可以为手性配位聚合物材料的进一步开发和利用提供科学依据。预计到项目结题时将发表SCI科研论文5-7篇（其中影响因子大于3.0的高质量国际期刊论文2-4篇）。

多孔手性配位聚合物在不对称催化、手性拆分、手性识别、信息存储、非线性光学材料等领域具有广泛的应用。本项目提出以基于手性α-氨基酸-水杨醛衍生物的还原Schiff碱为配体构筑多孔手性配位聚合物并研究其手性拆分性能。经过三年的研究工作，合成了一系列基于α-氨基酸的手性Schiff碱配体和还原Schiff碱配体，并成功得到了5个多孔手性配位聚合物。我们通过单晶衍射等测试手段对这些多孔配位聚合物的结构进行了表征，并研究了它们的手性拆分和荧光响应等性质。在本项目的资助下已发表SCI论文3篇，还有1篇论文将要投稿。