蛋白激酶C加强海马去甲肾上腺素释放机理
基本信息
结项摘要
本研究探讨高压肝阳上亢证分子机理。检测高血病肝阳上亢证及对照组（健康人，肝肾阴虚证）血浆去甲肾上腺素（NE），肾上腺素（E），酪氨酸羟化酶（TH）基因多态性，单胺氧化酶相关微卫星多态性。同时选用自发性高血压大鼠（SHR）加灌附子汤法复制高血压肝阳上亢证动物模型，测定该动物模型肾上腺组织TH蛋白质及mRNA表达水平。发现高血压病肝阳上亢证血浆NE，E含量显著高于对照组，其TH基因有显著扩增，且TH微卫量D11S4046中AI型明显增高；SHR肝阳上亢模型肾上腺组织TH蛋白质及mRNA表达增强。研究结果证实高血压肝阳上亢证上仍TH基因显著扩增，TH mRNA及蛋白质表达增强的特点，TH基因的过度表达可能是高血压肝阳上亢证的分子机理。
项目摘要
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数据更新时间：2023-05-31
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