沉淀液滴原位交联聚合法合成高性能凝胶微球粒子的研究

In this project, a new method of in situ cross-linking polymerization in precipitating droplet is provided to synthesize high performance gel microspheres. Firstly, monomer, initiator, and cross-linking agent are dissolved in water to prepare aqueous solution; then the aqueous solution is dropped to form aqueous droplets, and then into oil phase. The oil is heated, and then in situ cross-linking polymerization occurs in the precipitating droplet, and thus uniform high performance gel microspheres are synthesized. By simply choosing the monomers, different functional gel microspheres with high performance are obtained. In the study, we will systemically investigate the synthesis of gel microspheres with high ion exchange capacity and heparin-like structure, as well as the microsphere applications in advanced separation and blood purification.

本项目是利用沉淀液滴原位交联聚合法合成高性能聚合物凝胶微球粒子的研究。其方法是将单体、引发剂和交联剂配制成水溶液，将该溶液滴入油相中，形成水相液滴，液滴在油相中沉淀，沉淀过程中，液滴溶液中的单体和交联剂等发生原位交联聚合反应，直接合成尺寸大小均匀的高性能的凝胶微球粒子。利用该法通过简单调整聚合单体可制备出具有不同功能的高性能凝胶微球粒子，系统研究高离子交换容量凝胶微球粒子和类肝素凝胶微球粒子的合成，以及凝胶微球粒子在先进分离吸附和血液净化领域的应用。

本项目提出并验证了沉淀液滴原位交联聚合法合成高性能聚合物凝胶微球粒子。其方法是将单体、引发剂和交联剂配制成水溶液，将该溶液滴入油相中，形成水相液滴，液滴在油相中沉淀，沉淀过程中，液滴溶液中的单体和交联剂等发生原位交联聚合反应，直接合成尺寸大小均匀的高性能的凝胶微球粒子。利用该法通过简单调整聚合单体可制备出具有不同功能的高性能凝胶微球粒子，系统研究高离子交换容量凝胶微球粒子和类肝素凝胶微球粒子的合成，以及凝胶微球粒子在先进分离吸附和血液净化领域的应用。同时设计制备了沉淀液滴原位交联聚合的设备。在该基金的支持下，共发表SCI论文52余篇，其中第一标注7篇，第二标注15篇，其余标注30篇。