基于光波导的便携式生物芯片检测技术研究

In this project, a kind of portable technology for microarray detection based on optical waveguide will be designed and performed by using the property of optical waveguide which can make light transmit in a limited space, low-power cold light source LED driver and microlens array imaging technology. The main problems explored and solved in this project include four aspects: (1) the construction of orthogonal light field based on waveguide excitation. (2) the relationship between coupling technology of cold exciting light and the maximum utilization of the excitation light energy.(3) the study of the optimal parameters of microlens array for micro-imaging.(4) the research of the redundancy algorithm for high-throughput imaging data. All these studies are of great significant to the microarray detection with low-cost, accurate and convenient characteristic, as well as the promotion of the detection technology to a ‘anytime and anywhere’future. This technique and concerned instrument are expected to be widely applied in medical diagnosis, judicial expertise, sanitation and other fields.

本项目利用光波导可以使光波局限在有限区域内传播的性质，结合低功耗冷光源LED驱动和微阵列透镜成像技术，发展一种以光波导作为激发模式的低成本便携式生物芯片检测技术。本项目重点探索和解决以下四个方面问题：（1）波导激发正交光场的构建；（2）冷光源激发光耦合技术对激发光能量利用最大化的影响；（3）微阵列透镜用于生物芯片显微成像的最佳结构参数的考察；（4）高通量成像数据的冗余算法的研究。上述研究对实现生物芯片的低成本、准确、便捷的检测，对促进生物芯片检测技术向“随时，随地”方向发展都具有重要的意义，可以广泛应用在医疗诊断、司法鉴定以及环境检测等领域。

本项目利用光波导可以使光波局限在有限区域内传播的性质，结合低功耗冷光源LED驱动和微阵列透镜成像技术，发展一种以光波导作为激发模式的低成本便携式生物芯片检测技术。本项目重点探索和解决以下四个方面问题：（1）波导激发正交光场的构建；（2）冷光源激发光耦合技术及其激发能量补偿；（3）微阵列透镜应用于生物芯片检测系统；（4）高通量成像数据的冗余算法的研究。上述研究对实现生物芯片的低成本、准确、便捷的检测，对促进生物芯片检测技术向“随时，随地”方向发展都具有重要的意义，可以广泛应用在医疗诊断、司法鉴定以及环境检测等领域。