磁性碳纳米管的原位制备机理及性能研究

Magnetic nano-particles have a promising market in magnetic targeted positioning and drug controlled release areas. Suffering from the poor stability, bad biological compatibility and complex synthesis process, the magnetic nano-particles haven’t been widely application in medicine and biology fields. In our previous works, the functional carbon nanotubes (CNTs) encapsulated magnetic metal nano-particles are prepared in situ by the water-assisted CVD. The synthesized CNTs are filled with magnetic metal nano-particles and amounts of functional groups are introduced on the MWCNT surface due to the introduction of water vapor in CVD, by which, the stability of magnetic metal, biological compatibility and drug transport properties of the synthesized magnetic carbon nanotubes are significantly improved. In this work, the magnetic metal Ni, Co and Fe are designed to apply as catalyst active metal for CNTs synthesis and the reaction condition will be adjusted to improve the fill rate of magnetic metal nano-particles during CVD. The investigating route follows the strategy: from material preparation to structure-activity relationship researches, and then guide the synthesis of magnetic CNTs which have favourable stability, biological compatibility and drug transport properties. This work can provide powerful evidences and theoretical basis in the applications of magnetic CNTs to bio-pharmaceutical fields.

磁性纳米粒子在磁性靶向定位与药物控制释放等生物医药领域有着广阔的应用前景，但是其磁性稳定性不好，生物相容性较差及制备方法过程复杂等问题限制了其应用。在我们的前期工作中采用water-assisted CVD（混和水蒸气气相沉积法）的方法原位合成了功能化磁性纳米管。磁性纳米管的合成过程简单且纳米管表面引入了一定量的功能化基团，这在一定程度上可以解决上述的磁性纳米粒子在应用中的问题。基于water-assisted CVD法原位包裹磁性金属制得纳米管磁性较稳定、过程易于开展且可控、可实现原位功能化等优点，本项目拟采用water-assisted CVD原位包裹磁性金属Ni、Co、Fe制备磁性纳米管，围绕提高纳米管磁性稳定性，改进分散性、生物相容性和控制磁性纳米金属的尺寸及包裹率等核心问题展开系统研究。拟采用“磁性碳管制备→构效关系研究→反馈制备过程”的技术路线，指导合成稳定性强，生物相容性好及

磁性纳米粒子在异相催化剂回收、磁性靶向定位等应用领域有着广阔的应用前景，但是其磁性稳定性不好，制备方法过程复杂及生物相容性较差等问题限制了其应用。本项目旨在采用混合水蒸气气相沉积法（water-assisted CVD）原位制备表面功能化磁性碳纳米管，将其应用于催化领域，研究制备得到高效、易回收及方法简单的催化剂。研究内容主要包括优化water-assisted CVD包裹磁性金属Ni、Fe制得磁性纳米管的制备条件和研究磁性碳管表面功能化基团与其催化应用中的构效关系，以期得到磁性稳定，表面可控功能化及金属负载效率高的磁性碳纳米管。课题组严格按照研究计划，利用实验室研究、理论分析及计算化学方法相结合的综合研究方法进行了大量的研究工作，完成了原定的研究内容，取得了较大的进展。课题组采用water-assisted CVD 进行一步原位制备得到了具有填充率高、表面功能化及稳定性高的磁性纳米管，并将其作为催化剂载体负载Pd纳米颗粒应用于Heck反应中。研究了金属种类、金属担载量、碳管生长温度等催化剂制备条件对其结构及磁性的影响规律，并考察了其作为催化剂载体时的参与反应的作用机制，优化出了具有最佳催性能的催化剂。本课题较好的完成了研究目标，取得了系列研究新成果。此外，在开展本课题研究的同时，也发现了多个新的研究方向生长点，将在本课题结题后继续深入开展后续研究。