环境响应型“囊中囊”微囊膜的制备及梯级释放传质机理

The project of the National Natural Science Foundation of China (20906064) is going well and has obtained a number of innovative research results, that twenty-nine research papers have been published in academic journals including four papers featured in Front Cover or Back Cover of the international important journals, and the papers have been cited more than fifty time within two years; and three works have be applied for the Chinese invention patents. Based on these research foundations, a novel type of intelligent microcapsule membranes with capsule-in-capsule structure is proposed in this project, which could controllably release the loaded drug with a cascade controlled-release behavior that burst-release first and sustained-release second. The investigations in this project mainly focus on studying the formation methods and stability mechanisms of the O/W/O/W/O emulsions as the preparation templates of the composite microcapsule membranes, the controllability law of the emulsion microstructure, and preparation processes of the composite microcapsule membranes. Besides, we are planning to explore the relationship between the capsule-in-capsule structure and swelling-shrinking behavior, the cascade controlled-release behavior that burst-release first and sustained-release second, and build the kinetic model for the controlled-release mass-transfer process of drug molecules. The results will provide theoretical guidance for designing and preparing novel microcapsule membrane systems with controllable mass-transfer characteristics for targeted drug delivery systems.

申请人主持的青年科学基金项目进展顺利，已取得多项创新性研究成果，两年内已在高水平国内外学术期刊上发表论文29篇，包括国际重要刊物的封面及封底论文4篇，论文SCI及EI收录41篇次，论文在两年内已被国内外同行在SCI上引用50次以上；申请中国发明专利3项。在该青年基金项目研究基础上，本项目提出一种具有“囊中囊”结构的新型环境响应型智能复合微囊膜系统，探索其制备原理和方法、以及在病变部位依靠外界环境刺激实现先突释后缓释的梯级次序控制释放的释药新模式。研究作为聚合模板的四重复合乳液的制备及其稳定性、以及其微观结构的可控性规律，重点研究智能复合微囊膜的聚合反应工艺及其过程，探明微囊膜“囊中囊”结构与其膨胀－收缩特性的关系、以及智能复合微囊膜的环境响应型控释行为及其可控性，建立其环境响应型控释传质动力学模型。研究结果将为新一代控释速率可控、突释缓释相结合的智能微囊膜载体的设计与制备提供理论基础。

本项目设计制备了一系列具有“囊中囊”、“囊包球”结构的新型环境刺激响应型智能复合微囊系统，探索了其制备原理和方法、以及依靠外界环境刺激实现“先突释后缓释”等多种梯级次序控制释放的释药新模式。研究了作为聚合模板的四重复合乳液的制备及其稳定性、以及其微观结构的可控性规律，重点研究了智能复合微囊的聚合反应工艺及其过程，探明了微囊“囊中囊”及“囊包球”结构与其膨胀－收缩、膨胀－分解等特性之间的相互关系、以及智能复合微囊的环境响应型控释行为及其可控性。研究结果将为新一代控释速率可控、突释缓释相结合的智能微囊载体的设计与制备提供理论基础。