2-芳基烯丙基醇的不对称氢化
基本信息
结项摘要
光学活性的2-芳基丙醇是许多药物及天然产物合成中的重要中间体。然而，目前国际上使用不对称催化方法制备此类手性醇的研究不多，而且已知的方法都很繁琐。本课题研究以2-芳基烯丙基醇为原料，通过过渡金属催化的不对称氢化反应一步制备光学活性2-芳基丙醇的新方法。拟从现有的各种手性配体及过渡金属催化剂前体中进行筛选，发现合适的催化体系。通过进一步的优化，得到适合于此类反应的高效催化剂，建立合成手性2-芳基丙醇
项目摘要
项目成果
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数据更新时间：2023-05-31
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