恒河猴海洛因成瘾神经机制的ME-MRI和fMRI研究
基本信息
结项摘要
本项目建立具有条件反射的海洛因成瘾的恒河猴模型和对照组，在其海洛因成瘾过程中，对其进行基于血氧依赖水平的功能性磁共振成像（fMRI）和锰离子(Mn2+)增强的磁共振成像（ME-MRI）研究。通过图象数据处理，测定与对毒品渴求相关的脑功能区的Mn2+相对浓度及时间顺序，并将结果同fMRI和对照组结果比较，确定海洛因成瘾的神经机制。并用手术导航系统在活体上对相应的脑功能区进行活检及病理组织学研究，明确
项目摘要
项目成果
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数据更新时间：2023-05-31
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