基于核素-纳米金棒多功能纳米探针的肿瘤光热治疗研究

Taking advantage of the unique optical and surface chemical properties,gold-nanoparticle-mediated photothermal therapy shows particular promise for the destruction of cancer, which may be potentially useful in the clinical setting. In this proposal, light transport and thermal diffusion problems were further analyzed during gold nanorods enabled photothermal cancer therapy，a three-dimensional mathematical model based on modified Monte Carlo and finite element method to describe the light-gold-nanorods-tissue interactions was developed, and the effects of different laser sources, laser power, gold concentration and temperature distribution were studied based on this model. The multifunctional nanoprobes of radionuclide-gold nanorods labeled Asn-Gly-Arg (NGR) dipolymer were prepared for in vivo diagnosis and thearpy simultaneously.

纳米金良好的光学性质和表面化学能力能够对肿瘤组织进行准确定位和高效光热治疗，有望成为癌症临床治疗的新手段。本项目分析纳米金靶向活体肿瘤光热治疗的难点问题，深入研究活体光热治疗过程中光-纳米金棒-生物组织的光传输和热扩散问题，建立基于改进蒙特卡洛和有限元方法的光热效应模型，分析不同参数条件下生物体内的温度分布；制备高效稳定的核素68Ga-纳米金棒双标靶向天冬酰胺-甘氨酸-精氨酸（NGR）二聚体的多功能纳米探针，实现探针的诊断治疗一体化，为研究多功能纳米探针靶向活体肿瘤光热治疗奠定基础。

纳米金良好的光学性质和表面化学能力能够对肿瘤组织进行准确定位和高效光热治疗。在深入研究活体光热治疗过程中光-纳米金棒-生物组织的光传输和热扩散问题上，我们成功建立了基于改进蒙特卡洛和有限元方法的光热效应模型，分析不同参数条件下生物体内的温度分布；制备高效稳定的RGD靶向纳米金棒探针，实现靶向活体肿瘤的在体成像；并探索制备了具有光学/CT双模成像性能的纳米金簇，为研究纳米金多功能探针靶向活体肿瘤成像和治疗奠定了基础。