基于静息态功能磁共振单侧静脉源性耳鸣的脑中枢化机制研究

Tinnitus centralization could lead to abnormal neural activity, which was considered as the critical factor accountable for tinnitus to be difficult to cure in the clinic. Previous studies preliminary supported this idea by focusing on investigating the neural originated tinnitus patients. But for another important kind of tinnitus – venous originated tinnitus, whether there was similar feature remains unclear. In our research group, for the first time, the etiology of venous originated tinnitus was successfully uncovered and the tinnitus centralization effects in venous originated tinnitus were further detected. However, its mechanism is still unclear. We hypothesized that neural network radiologic landmarks could objectively evaluate the severity and the prognosis of venous tinnitus centralization. In this study, we would like ① to define an accurate, stable, and featured model of brain functional parcellation and key nodes of neural network in unilateral venous originated tinnitus patients, on the basis of the results of Human Connectome Project (HCP) and multi-model brain network atlas, as well as the supervoxel-based algorithm for the whole brain, to construct the venous originated tinnitus featured neural network study framework; ② to analyze and illustrate the differences of functional connectivity as well as topological features among neural networks between venous tinnitus patients groups with different clinical features, then identify the neurobiological biomarker with high resolution by using discriminant analysis in pattern recognition technology; ③ to analyze the potential relationship between the neural network reorganization features and the pathological meanings, and then to construct a model with neural activity imaging features of venous originated tinnitus. This study would uncover the mechanism of tinnitus centralization in unilateral venous originated tinnitus, providing a theoretical foundation for the innovative methods of clinical diagnosis and treatment of tinnitus.

耳鸣脑中枢化是导致脑神经活动异常的本质，是造成疾病难以根治的关键因素。既往围绕神经源性耳鸣的研究初步证实上述学术观点，而另一重要类别——静脉源性耳鸣，是否也具类似特征？申请人通过明确此类耳鸣的“责任病灶”，更进一步发现：病因明确的静脉源性耳鸣也存在脑中枢化现象，但机制仍不明了。我们推测，静脉源性耳鸣脑中枢化程度可由神经网络影像学表征客观评估并预测临床预后。本研究拟通过①基于人脑连接组计划研究成果及多模态脑网络图谱，结合超体素聚类算法，定义稳定、准确、特征性的静脉源性耳鸣脑中枢化功能脑区分割模式及神经网络节点，搭建耳鸣神经网络研究框架；②阐释不同临床特征的静脉源性耳鸣神经功能连接模式及拓扑属性差异，利用模式识别技术中的判别分析确立高精度神经网络影像学表征；③探索影像学表征所映射的神经活动病理特征，构建神经活动影像表征模型，充分揭示静脉源性耳鸣脑中枢化机制，为创新耳鸣的临床诊疗提供理论支撑。

耳鸣脑中枢化是导致脑神经活动异常的本质，是造成疾病难以根治的关键因素。本研究通过①基于人脑连接组计划研究成果及多模态脑网络图谱，结合超体素聚类算法，定义稳定、准确、特征性的耳鸣脑中枢化功能脑区分割模式及神经网络节点，搭建耳鸣神经网络研究框架；②阐释不同临床特征的耳鸣神经功能连接模式及拓扑属性差异，利用模式识别技术中的判别分析确立高精度神经网络影像学表征；③探索影像学表征所映射的神经活动病理特征，构建神经活动影像表征模型，揭示耳鸣脑中枢化机制，初步验证了“耳鸣脑中枢化程度可由神经网络影像学表征客观评估并预测临床预后”这一科学假说，为创新耳鸣的临床诊疗提供理论支撑。