18F标记归巢肽靶向肿瘤间质纤维蛋白的PET显像研究
基本信息
结项摘要
使用标记配体的肿瘤细胞靶向诊断虽然取得了一些进展，但由于肿瘤细胞的异质性和缺乏相同的靶点，肿瘤的放射性核素标记探针的靶向诊断需要进一步改进。本课题根据多种实体肿瘤间质存在纤维蛋白沉积的共性特征，提出肿瘤间质归巢靶向诊断原理，以18F标记肿瘤间质归巢肽，如CREKA（18F-CREKA）为探针，进行肿瘤间质靶向显像。探讨该技术早期诊断实体瘤和转移瘤的敏感性和它对常见各种肿瘤的实用性。期望通过由实体瘤细胞到间质纤维蛋白的靶向改变，建立一种敏感、特异、多种实体瘤通用的正电子核素扫描诊断方法。在研究过程中探索发现更有价值的核素标记肿瘤探针。因此本课题是使用正电子核素标记与肿瘤间质特异结合的归巢肽，来靶向实体瘤间质，建立肿瘤PET显像的新理论和新方法的尝试。如果该技术能够实现肿瘤的早期诊断，推测它也能用于实体瘤的体内放射治疗。
项目摘要
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数据更新时间：2023-05-31
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