年龄性和病理性人眼高阶像差增大机理及其与人眼散射相关性探索研究

Ocular high-order aberrations increase with age, complications after refractive surgery, keratoconus and other eye diseases, and its influence on visual function will involve all aspects of people's life. Many domestic and foreign research institutions have conducted in-depth studies on the effect of high order aberration on visual function. However, the understanding of the mechanism of age-related and pathological high-order aberration enhancement is quite limited, and no formal literature has been reported yet. Based on the previous research results and the investigation of the literature in this field, the applicant found that there may be an internal relationship between high-order aberrations and ocular scatter. Considering the human eye's intelligence and researchers' understanding of the mechanism of increase in ocular scatter, the applicant put forward a conjecture: increase in ocular scattering will induce high-order aberrations! In order to validate the hypothesis, this project intends to develop a high-order aberrations and ocular scatter objective measurement system; and then investigate the relationship between increase of high-order aberrations with ocular scatter, and find out whether ocular scatter induces high order aberrations; and explore the mechanism of the age-related and pathological high-order aberrations and its correlation with ocular scatter; and finally provide useful guidance for the prevention and control of diseases such as age-related visual impairment, refractive surgery complications and keratoconus and visual function maintenance of human eyes.

人眼高阶像差会因年龄的增大、屈光术后并发症以及患有圆锥角膜等眼病而增大，其对视功能的影响会涉及到人们生活的方方面面。国内外多家研究机构针对高阶像差对视功能影响已经进行了深入的研究。但是对年龄性和病理性高阶像差增大机理的认识还相当有限，尚未见正式文献报道。申请人根据前期研究结果以及对本领域文献的调研分析发现高阶像差和人眼散射之间可能存在内在联系。考虑到人眼的智能性以及研究人员对人眼散射增大机理的研究结果，申请人提出了一个猜想：人眼散射增大会诱发高阶像差！为了验证该猜想，本项目拟研制建立一套人眼高阶像差和散射客观测量系统，并以此为基础平台深入研究年龄性和病理性高阶像差增大与人眼散射之间的关系，解答人眼散射是否诱发高阶像差的疑问，探索年龄性和病理性高阶像差增大的机理，为年龄性视功能衰退、屈光术后并发症及圆锥角膜等疾病的防控和人眼视功能维护提供有益指导。

人眼高阶像差会因年龄的增大、屈光术后并发症以及患有圆锥角膜等眼病而增大，其对视功能的影响会涉及到人们生活的方方面面。但是对年龄性和病理性高阶像差增大机理的认识还相当有限，尚未见正式文献报道。申请人根据前期开展的研究结果申请人提出了一个猜想：人眼散射增大会诱发高阶像差！为了验证该猜想，本项目研制建立了一套人眼高阶像差和散射客观测量系统，并研究了屈光手术后高阶像差增大与人眼散射之间的关系。项目主要研究成果包括：.（1）研制建立国内首套人眼高阶像差和散射客观测量系统，系统可以同步测量人眼高阶像差和散射客观数据，为项目研究和未来眼视光研究提供技术和设备支持。.（2）开展了屈光手术对人眼高阶像差的影响研究。研究表明，屈光手术过程中会在一定程度上降低高阶像差，随着术后时间的延长高阶像差会逐渐增大。.（3）开展了屈光手术对人眼散射的影响研究。研究表明，屈光手术过程中人眼散射会大幅增大，随着术后时间的延长散射量会逐渐降低，但是在一年范围内散射量始终大于术前。.（4）开展了屈光术后高阶增大与人眼散射的相关性研究。研究表明，术后半年和屈光术后一年相对于术前的RMS值变量均与屈光手术后人眼客观散射系数（OSI）的变化量具有明显的相关关系，这与人眼散射增大诱发高阶像差的猜想是一致的。