阴离子通道的设计构建及其跨膜传输行为研究

Transmembrane transport of anions in vivo is the pathological basis of heart failure and essential hypertension. Therefore, it is an important task to study the process of anion transport and clarify its molecular mechanism. Based on applicant’s long term research of macrocyclic aromatic hydrocarbon, according to the principle of bionics, the research purpose of this project is to design and fabricate anion selective channel, study their properties of selective anion transport and clarify the mechanism. The study mainly includes three parts: ① Synthesize a series of pillararenes in response to specific anions based on the two-element design strategy of "ion recognition-cavity fixation"; ② Fabricate pillararene-functionalized anion gates by the strategy of host-guest based self-assembly; ③ Study the process of selective anion transport, and elucidate the mechanism of selective anion transport, and provide a basis for deeper understanding of the pathological mechanism of diseases related to anion channels.

生命体内阴离子跨膜传输过程是心力衰竭和原发性高血压等疾病的病理基础。因此，研究阴离子传输过程，阐明其传输的分子机制是一项重要的任务。本项目是申请者在长期从事大环芳烃化学研究的基础上，依据仿生原理，设计构建阴离子门控通道，研究其对阴离子的选择性传输性质，阐明选择性传输分子机制。研究主要包括三部分：①依据“离子识别-空腔固定”的二元设计策略，合成一系列对特定阴离子响应的柱芳烃；②通过主-客体作用将柱芳烃组装到纳米通道，构建阴离子门控通道；③研究其选择性传输阴离子的门控过程，阐明阴离子选择性传输分子机制，为人们更深入理解阴离子通道相关疾病的发病机制提供依据。

生命体内阴离子跨膜传输过程是心力衰竭和原发性高血压等疾病的病理基础。因此，研究阴离子传输过程，阐明其传输的分子机制是一项重要的任务。本项目是申请者在长期从事大环芳烃化学研究的基础上，依据仿生原理，设计构建阴离子门控通道，研究其对阴离子的选择性传输性质，阐明选择性传输分子机制。研究主要包括三部分：①依据“离子识别-空腔固定”的二元设计策略，合成一系列对特定阴离子响应的柱芳烃；②通过主-客体作用将柱芳烃组装到纳米通道，构建阴离子门控通道；③研究其选择性传输阴离子的门控过程，阐明阴离子选择性传输分子机制，为人们更深入理解阴离子通道相关疾病的发病机制提供依据。