基于诊疗一体化的新型多功能双面神纳米粒子的设计、合成与应用研究

Janus nanoparticles have attracted increasing attention for biomedical applications because of their asymmetry in structure and diversity in composition. The study idea of project is from design, synthesis to application and explores the synthetic strategy of novel multifunctional Au nanostar-hollow mesoporous inorganic nanoparticle Janus composite materials. The intensive study of formation mechanism could be achieved. From the perspective of application, the project will construct the novel multifunctional theranostic agents for combined active tumor-targeting, multi-modal imaging, photothermal, chemo- or photodynamic therapy, high payload of drug with stimulus-responsive drug release. From the celluar and animal level, the active tumor-targeting multifunctional Janus nanotheranostic agents for imaging-guided synergistic photothermal, chemo- or photodynamic therapy and biosafety will be systematically investigated. This research aims to create a novel method for controllable preparation of multifunctional Janus nanomaterials and construct the synergistically integrated multifunctional Janus nanotheranostic agents based on individual different needs of tumor diagnosis and treatment by selective surface modification of Janus nanoparticles with different targeting molecules and anti-cancer drugs, which further promote the application of multifunctional Janus nanomaterials in the theranostics of serious diseases.

双面神(Janus)纳米粒子因在结构上的不对称性和组成上的多样性在生物医学领域具有良好的应用前景，并越来越受到研究者的重视。本项目以“设计－合成－应用”为研究思路，探索新型多功能Au纳米星－中空介孔无机纳米粒子Janus复合材料的可控合成策略, 深入研究其形成机理。从应用角度出发，构建对肿瘤主动靶向、多模式成像、光热、化学或光动力学联合疗法、高载药量和刺激响应释放药物有机融合的新型多功能Janus纳米诊疗剂。从细胞和动物水平，对多功能Janus纳米诊疗剂的影像导航的肿瘤主动靶向热疗、化疗或光动力学疗法协同效果以及生物安全性进行系统评价。通过本项目的研究，建立可控合成多功能Janus纳米材料的新方法，并可以根据肿瘤诊疗个体化不同的需要，表面选择性修饰不同的靶向分子或抗癌药物，构建出更有针对性的一体化多功能Janus纳米诊疗剂，进一步推动多功能Janus纳米材料在重大疾病诊疗中的应用研究。

双面神(Janus)纳米粒子因在结构上的不对称性和组成上的多样性在生物医学领域具有良好的应用前景，并越来越受到研究者的重视。本项目以“设计－合成－应用”为研究思路，合成了一系列新型多功能Janus复合纳米材料, 并研究其形成机理。基于制备的纳米粒子构建出体内外多模式成像、光热、化学或光动力学联合疗法、高载药量和刺激响应释放药物有机融合的肿瘤诊疗剂。通过本项目的研究，建立可控合成多功能Janus纳米材料的新方法，进一步推动多功能Janus纳米材料在肿瘤诊疗中的应用研究。在项目资助下，在Angew. Chem. Int. Ed., Biomarerials, Adv. Funct. Mater., Chem. Sci. 和Chem. Mater等发表SCI论文16 篇。