特殊构型磁性-光热-荧光三功能纳米探针Fe3O4-Au@SiO2@QDs的研制及对肝癌的研究

The study of bifunctional nanoprobe is one of the most research hotsports in material science and related medical domain. However, the bifunctional probe still cannot to realize the composite effect in both accurate positioning and efficient therapy, due to the shotcome of the material design. In order to improve this status, we will synthesis a special tri-functional Janus type Fe3O4-Au@SiO2@QDs complex cell nanoprobes via combine static butt joint on the interface of oil/water and mesoporous plugging, the probe will be used in magnetic orientation (Fe3O4), photothermal therapy (Au nanostar) and optical treacing (QDs). We will explore the variation of MRI signal and photothermal effect and therefore clarify the enhancement mechanism of MRI and photothermal effect under the motivation of electromagnetic field, via building a charges passageway between Fe3O4 and Au; the effect of the structure modulation for the Au star to narrowing the absorption peak that can be separated with QDs emission peak will also be studied, which can reveal the coexist and co-enhancement mechanism between photothermal effect and fluorescent emission. The application of this tri-functional Janus probes can be not only expanded to the integration of the diagnosis and treat studies for other cancers, but also provide useful ideas in the study of new multi-functional co-existent nano materials.

双功能纳米探针是目前材料科学及医学领域的研究热点，但由于其材料结构设计原因尚不能同时进行肿瘤转移示踪及高效治疗，亟待研制多功能及高功效的探针。本项目首次采用对Fe3O4的单边屏蔽、链接Au球后再生长出金星的方法，实现磁性与光热的双功能；再利用介孔填塞法，合成Fe3O4-Au@SiO2@QDs三功能纳米探针；该探针具有Janus双面人特殊构型，可用于对肝癌的磁性定位、光热治疗及荧光示踪。将探索Fe3O4-Au系统中的能带耦合所致核磁共振信号和光热效应的变化，阐明构建两粒子间电荷通道对系统在电磁场激励下核磁共振信号或光热效应的增强机理；研究Au@SiO2@QDs系统中Au纳米星的结构调制对缩窄纳米星的吸收峰、并与量子点的吸收与发射峰完全分离的影响，揭示光热效应与荧光发射的共存机理与增强机制。这种三功能双面人特殊构型探针可拓展至对其它肿瘤的诊疗一体化研究，还可为研制多功能共存的新型材料提供思路。

双功能纳米探针是目前材料科学及医学领域的研究热点，但由于其材料结构设计原因尚不能同时进行肿瘤转移示踪及高效治疗，亟待研制多功能及高功效的探针。本项目首次采用对Fe3O4的单边屏蔽、链接Au球后再生长出金星的方法，实现磁性与光热的双功能；再利用介孔填塞法，合成Fe3O4-Au@SiO2@QDs三功能纳米探针；该探针具有Janus双面人特殊构型，可用于对肝癌的磁性定位、光热治疗及荧光示踪。将探索Fe3O4-Au系统中的能带耦合所致核磁共振信号和光热效应的变化，阐明构建两粒子间电荷通道对系统在电磁场激励下核磁共振信号或光热效应的增强机理；研究Au@SiO2@QDs系统中Au纳米星的结构调制对缩窄纳米星的吸收峰、并与量子点的吸收与发射峰完全分离的影响，揭示光热效应与荧光发射的共存机理与增强机制。这种三功能双面人特殊构型探针可拓展至对其它肿瘤的诊疗一体化研究，还可为研制多功能共存的新型材料提供思路。