基于fMRI的儿童良性Rolandic癫痫的皮层语言网络发育的研究

Children with benign Rolandic epilepsy (RE) are often accompanied by speech dysfunction, but the pathogenesis is largely unclear. Based on our previously established framework, this project will test the hypothesis that language impairments in RE may be preclinically abnormal regulation of the language cortical network, leading to atypical trajectories of linguistic circuit and their interactions with other cortical networks. Therefore, the aim of this project is to recruit 5 to 7-year-old RE children, combined with multimodal magnetic resonance imaging (MRI) parameters (morphology, structure, function and metabolism) and multidimensional language development as well as cognitive neural scale with one year longitudinal tracking. First, we will build multidimensional MRI correlates of cortical language network in RE children, and analyze the cortical development trajectory following one year. Then, the characteristic parameters of the above linguistic network change are extracted by machine learning method. The data are predicted to develop a year later to obtain a potential language loop for multimodal imaging bio-markers. This will help to reveal the abnormal cortical development trajectory of Rolandic epilepsy children and the neurological mechanism of verbal dysfunction. It is of great scientific significance and clinical guidance value for understanding the language cortical development and the language protection of children 's brain surgery.

儿童良性Rolandic癫痫常伴有言语功能障碍，但其发病机理尚不明确。结合我们前期研究，本项目假设Rolandic癫痫患儿语言障碍可能是临床发病前期皮层网络的异常发育调控，导致语言环路及其与其它皮层网络交互的异常的发育轨迹。因此，本项目旨在招募5-7岁Rolandic癫痫患儿，联合多模态磁共振指标（形态、结构、功能及代谢）和多维度语言发育认知神经量表以及一年的纵向跟踪，首先定位Rolandic癫痫皮层语言网络环路的多模态磁共振关联，然后分析一年内的皮层发育轨迹，随后使用机器学习的方法抽取上述语言环路异常改变的特征参数进行分类，并使用一年前数据预测一年后的发展，从而获取潜在的语言环路多模态影像生物学标记。这将有助于揭示Rolandic癫痫儿童异常的皮层发育轨迹及其言语功能障碍的神经机制，为理解个体语言皮层发育和儿童颅脑手术语言保护提供依据，具有重要的科学意义和临床指导价值。

Rolandic癫痫常伴有言语功能障碍，但其发病机理尚不明确。为探讨Rolandic癫痫儿童语言发育的神经解剖功能基础以及其异常的解剖功能改变，我们开展了以下几方面的工作：1）基于rs-fMRI对Rolandic癫痫大脑半球偏侧化异常的研究，研究表明Rolandic癫痫儿童在语言加工区域表现出大脑半球偏侧化的改变，提示Rolandic癫痫儿童异常的局部分离和半球间整合。2）基rs-fMRI对Rolandic癫痫儿童左额下回亚区的不同改变模式进行研究，揭示了不同亚区可能参与与Rolandic癫痫儿童语言功能损害相关的不同神经回路，为Rolandic癫痫儿童的语言功能损伤机制提供了一定依据。.在原研究计划的基础上，增加了1）基于3D-T1WI结构数据对Rolandic癫痫的脑表面形态学分析研究，为Rolandic患儿的认知功能障碍提供影像学依据。2）基于机器学习的Rolandic癫痫儿童的脑龄评估研究，寻找基于影像学量化判断脑发育进程的生物学标记。.综上，通过本课题的研究，明确了Rolandic癫痫儿童语言发育相关的大脑结构和功能的异常，揭示了Rolandic癫痫儿童异常的皮层发育轨迹及其言语功能障碍的神经机制，为理解个体语言皮层发育和儿童颅脑手术语言保护提供依据，具有重要的科学意义和临床指导价值。