多功能吡啶类稀土纳米荧光材料合成及其荧光发光成像平台的构建

Rare earth luminescent material has a light emitting good monochromaticity, rich colors, internal quantum efficiency. This material is very important in terms of fluorescence, anti-counterfieting, color display, sensor, electroluminescence luminescent, agricultural and biological and medical and other aspects. At present most of rare earth complexes light-emitting device generally has poor stability, low efficiency, fast aging. There are mainly two ways to improve ligh-emitting device propertires: synthesizing materials with better properties and improving structure. The intention of this project is apply in synthesis of the new nano fluorescent materials and enhance its fluorescence properties as a target. Explore the relationship between its structure and luminescent properties, Combined with our current research work regarding the effects of nano fluorescent materials luminescence properties of some of the major issues for further study. In order to achieve the design, synthesis and development of new rare earth complexes and Improved structure for light emitting devices and performance. At the same time using chemiluminescence high sensitive combined with sol gel technique, preparation of a series of complexes of rare earth doped nanoparticles, on the basis of construction of multifunctional composite nano probe. Exploration of the early application in the disease diagnosis and molecular imaging; Using the composite probe through the comparison between the different detection methods to improve the diagnosis and analysis of accuracy. The realization of the project will have important academic value and practical significance.

稀土发光材料有着发光单色性好、颜色丰富、内量子效率高等优点，在荧光、防伪材料、彩色显示、传感器、电致发光以及农用发光材料、生物和医学等方面都具有很重要的应用。目前大多稀土配合物发光器件却普遍存在着稳定性差、效率低、老化快等缺点，提高发光性能的方法主要有两种：合成性能更优良的新材料及改进器件的结构及性能。本申请拟在以合成新型纳米荧光材料和提高其荧光性能为目标，进一步探讨其结构和发光性能两者之间的关系。结合我们目前研究工作就影响荧光材料发光性能的一些主要问题作进一步的探讨，以期达到设计、合成和开发新型稀土配合物和改进发光器件的结构及性能的目的。同时利用化学发光的高灵敏结合溶胶凝胶技术，制备系列稀土配合物掺杂纳米粒子，以此为基础构筑多功能复合纳米探针。探索其在疾病早期诊断和分子成像中的应用，利用复合探针通过不同检测方法间的比较提高诊断和分析的准确性。该项目的实现将具有重要的学术价值和实际意义。

（1）计划要点是：（详细见项目申请书和资助项目项目计划任务书）. 新型纳米尺寸的金属有机化合物具有好的生物降解能力，且有机物部分容易修饰，有可能实现材料的多功能化，通过荧光探针技术和电子自旋共振技术实现活细胞中自由基的检测。探索其在疾病早期诊断和分子成像中的应用，利用复合探针通过不同检测方法间的比较提高诊断和分析的准确性。同时明确稀土配合物的抗肿瘤机制和构效关系，从而设计、合成出新型结构的高效低毒稀土配合物。在项目期限内拟在较高级别的期刊上发表创新性较强的文章1篇。.（2）研究计划执行情况. 项目成员已经按照项目计划任务书承诺的指标高水平、高质量圆满地超额完成了预期计划任务和指标。研究成果共计发表论文10篇，其中SCI检索1篇，EI检索4篇,国内期刊3篇，全国会议论文2篇，申请国家专利1 项。在该项目支持下，总计培养硕士研究生4名，青年教师3名。