2'-5'寡腺苷酸合成酶在系统性红斑狼疮的系列研究
基本信息
结项摘要
本课题在前期完成了系统性红斑狼疮（SLE）患者的外周血基因表达谱研究，筛选到了一批以2'-5'寡腺苷酸合成酶（OAS）为代表的干扰素诱导表达蛋白，作为可能的SLE候选干预靶点。本研究试将OAS抑制剂用于自发性SLE动物模型BXSB小鼠，通过观察蛋白尿、自身抗体滴度、免疫复合物性肾小球肾炎、存活率/存活时间等指标，评估其可能的治疗效应；并进一步拟进行OAS参与SLE的发病机理研究，提出OAS可能与S
项目摘要
项目成果
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数据更新时间：2023-05-31
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