血管壁高频超声弹性显示微成像研究

基本信息
批准号:39970208
项目类别:面上项目
资助金额:14.00
负责人:万明习
学科分类:
依托单位:西安交通大学
批准年份:1999
结题年份:2002
起止时间:2000-01-01 - 2002-12-31
项目状态: 已结题
项目参与者:李俊博,李仰梅,周永进,刘照泉,梁文新,陆明珠,江安琴,周晓东
关键词:
血管内超声信息处理弹性显微成像
结项摘要

The elasticity of arterial wall tissues has very close relationship with physiological status and pathological changes of cardiovascular system. Strain estimation and elasticity imaging has drawn much attention for its low cost and risk and it is very valuable for diagnosis and therapy of cardiovascular diseases to apply this modality. During the last three years, we make much effort to research the biomechanical properties and microscopic elasticity imaging of artery wall mainly using the Intravascular Ultrasound (IVUS) technique. Our studies include displacement and strain estimation of artery wall, elasticity reconstruction of artery wall, experiments of mimicking phantom and in vitro and in vivo porcine artery. Furthermore we extend our research to strain estimation of soft tissue and shell of microbubble and quantitative evaluation of soft tissue contusion. Achievements acquired in our research are ①Displacement and strain estimation of artery wall and soft tissue utilizing ultrasound rf signal, including a method based on Principle Component Analysis (PCA) neural network and a method using the matched filter in time-scale domain based on wavelet transform to position the regular scatterer and calculate the local scatterer spacing and its change. ②Displacement and strain estimation of artery wall and soft tissue utilizing ultrasound images, including a Genetic Algorithm Based Optical Flow Method (GAOF) and a Genetic Algorithm Based Correlation Feedback Technique (GACF). ③Applying elasticity reconstruction method to artery wall and soft tissue, acquiring the 'real'elasticity distribution images. ④Having made a lot of experiments of mimicking phantom,in vitro and in vivo artery and soft tissue and improved strain estimation method and the strategy of the experiments. These studies may have potentials to provide new technological means for monitoring and evaluating Percutaneous Transluminal Coronary Angioplasty (PACT) procedure and elasticity characterization of soft tissue.

提出将血管壁高频超声弹性显微成像的新方法,将血管力学在体研究推进到亚同毫米微结构层次主要研究(1)血管内高频超声传播特性和图像预处理;(2)非刚性血管组织线性与非线性应变小误差位移与应变声估计方法;(3)线性与非线性应变血管弹性重构理论与方法停?)对PTCA过程临控与疗效评价的关键技术。对血管力学、心血管系统生理与心血管评价等具有重要价值。

项目摘要

项目成果
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数据更新时间:2023-05-31

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万明习的其他基金

批准号:11274250
批准年份:2012
资助金额:85.00
项目类别:面上项目
批准号:39470212
批准年份:1994
资助金额:8.00
项目类别:面上项目
批准号:10874137
批准年份:2008
资助金额:38.00
项目类别:面上项目
批准号:30570487
批准年份:2005
资助金额:25.00
项目类别:面上项目
批准号:39570217
批准年份:1995
资助金额:9.00
项目类别:面上项目
批准号:30630024
批准年份:2006
资助金额:135.00
项目类别:重点项目
批准号:69101002
批准年份:1991
资助金额:4.70
项目类别:青年科学基金项目
批准号:81771854
批准年份:2017
资助金额:55.00
项目类别:面上项目
批准号:30270404
批准年份:2002
资助金额:24.00
项目类别:面上项目

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