SSd抑制肝肿瘤血管形成及抗肿瘤的分子机制研究
基本信息
结项摘要
肿瘤新生血管生成与恶性肿瘤的发生、发展和转移关系密切，环氧化酶-2（COX-2）密切参与了肿瘤新生血管的生成，可调控血管内皮细胞生长因子（VEGF）的产生和金属基质蛋白酶-2（MMP-2）的激活，促进肿瘤血管的形成。我们前期的研究发现，从传统中药柴胡中分离、提取出来的活性成份柴胡皂甙d（SSd）具有抑制COX-2的药理作用。为此，本项目拟通过鸡胚绒毛尿囊膜法微血管生成模型及乙型肝炎病毒（HBV）和黄曲霉毒素（AFB1）协同致小鼠肝癌模型，观察SSd对活体微血管形成的影响和小鼠肝肿瘤组织中COX-2、VEGF表达以及MMP-2活性的调控作用及其相互关系，探讨SSd抑制肝肿瘤血管形成及抗肿瘤的分子机制，为开发、应用SSd防治肿瘤提供科学的理论依据。
项目摘要
项目成果
{{i.achievement_title}}
{{i.achievement_title}}
暂无此项成果
数据更新时间：2023-05-31
其他相关文献
Efficient photocatalytic degradation of organic dyes and reaction mechanism with Ag2CO3/Bi2O2CO3 photocatalyst under visible light irradiation
Efficient photocatalytic degradation of organic dyes and reaction mechanism with Ag2CO3/Bi2O2CO3 photocatalyst under visible light irradiation
Influencing factors of carbon emissions in transportation industry based on CD function and LMDI decomposition model: China as an example
Influencing factors of carbon emissions in transportation industry based on CD function and LMDI decomposition model: China as an example
Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-β/Smad signaling
Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-β/Smad signaling
An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function
An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function
The Role of Osteokines in Sarcopenia: Therapeutic Directions and Application Prospects
The Role of Osteokines in Sarcopenia: Therapeutic Directions and Application Prospects
程延安的其他基金
相似国自然基金
柴胡皂甙d抑制转基因小鼠肝肿瘤形成的分子机制
茶多酚抗肿瘤血管生成的细胞分子机制研究
PEDF抑制血管生成和抗肿瘤的作用及活性部位
新型LSD1抑制剂抗肿瘤作用及分子机制研究