纤维素生物质颗粒的刺激-响应性及其作为可控释放功能材料的研究

Biomass particles such as cellulose particles have excellent biocompatibility, biodegradability, renewability, as well as low toxicity, and are therefore ideal biocompatible particulate materials for self-assembly at fluid interface and encapsulation materials. If the self-assembly and encapsulation can be made reversible, they could be good functional materials for encapsulation of drugs and controlled release systems. This project tries to investigate possibility and mechanisms of endowing cellulose particles stimuli-responsiveness so as to be able to reversibly self-assemble at fluid interface for constructing controlled release systems via reversible in situ hydrophobization. The study will primarily focus on the possible routes to endow cellulose particles surface activity so as to be able to self-assemble at fluid interface via in situ hydrophobization in aqueous media, and the triggers for removing the in situ hydrophobizaiton, followed by exploring the construction of the controlled release systems and their working principles. It is expected that the study of this project will provide scientific routes and relative triggers of endowing biomass particles like cellulose particles stimuli-responsiveness, as well as the fundamentals of their applications in encapsulation of drugs and controlled release systems.

生物质颗粒具有优良的生物相容性、生物降解性、可再生性以及低毒性等优异特征，是一种理想的生物相容性自组装和包覆材料。如果能使相应的自组装和包覆过程可逆化，就能使其成为一种理想的功能材料，应用于药物包埋和可控释放体系。本项目试图以纤维素颗粒为研究对象，探索通过可逆原位疏水化作用赋予其刺激-响应性，进而能够在流体界面发生可逆自组装、构建可控释放体系的可行性和相关机理。重点探索在水介质中通过原位疏水化作用赋予其表面活性、进而能够在流体界面进行自组装的具体途径，以及可能的解除原位疏水化作用的触发机制，在此基础上进一步探索可控释放体系的构建和相关作用原理。相信通过本项目的研究，将探索出赋予纤维素类生物质颗粒刺激-响应性的科学途径和相关触发机制，为其在药物包埋及可控释放领域的潜在应用提供理论基础。

生物质颗粒具有优良的生物相容性、生物降解性、可再生性以及低毒性等优异特征，是一种理想的生物相容性自组装和包覆材料。如果能使相应的自组装和包覆过程可逆化，就能使其成为一种理想的功能材料，应用于药物包埋和可控释放体系。本项目以纤维素颗粒为研究对象，通过可逆原位疏水化作用赋予其刺激-响应性，进而能够在流体界面发生可逆自组装、构建可控释放体系。重点探索了在水介质中通过原位疏水化作用赋予其表面活性、进而能够在流体界面进行自组装的具体途径，以及解除原位疏水化作用的触发机制和相关原理。通过本项目的研究，探索出赋予纤维素类生物质颗粒刺激-响应性的科学途径和相关触发机制，为其在药物包埋及可控释放领域的潜在应用提供理论基础。