稀土暴露的健康效应研究

The rare earth contents of well water, soil, crops and air, as well as the blood of local residents.in rare earth ore area of Xunwu County in Jiangxi Province are significantly higher than that.in control area. Exposing to such levels of rare earth contents, there were no significant effects.on the results of most physiological and biochemical indexes. However, the results in part of.indexes showed that there were some positive or negative effects on the cardiovascular.function, blood calcium and blood sugar. The results of physical growth and development,.intelligence and immunology examination of children in rare earth exposure area indicates.that exposure to rare earth elements had negative effects on health. The matched case-control.study suggests that the incidence of leukemia may relate to rare earth elements..2. The spraying operators exposure to agriculture-use rare earth for short time may significantly.increase the rare earth contents in blood and induce some physiological and biochemical.instant changes. These changes were in normal range..3. Lanthanum chloride and cerium chloride at certain concentrations may inhibit the growth of.HL-60 and NB4 leukemic cells. Two different effects of cerium chloride on the growth of T.lymphocyte progenitors were observed. Lower concentrations of cerium chloride induced.promoting effects, but higher concentrations induced inhibitory effects and promoted the.leukemic cells to apoptosis. Rare earth compounds had protective effects on mice that.challenged by lethal dose of endotoxin and inhibited the scar formation during wound healing.

通过对稀土微肥喷施区、轻重稀土矿区、对照区的环境、食物及人体中稀土富集水平检测，评估人群稀土暴露水平；开展现患、病例对照调查和回顾－前瞻研究，并用新技术进行动物实验，从分子水平研究稀土在血液、生殖和免疫系统等方面的生物效应，并观察稀土对神经系统的影响。综合环境检测、生物效应研究及人群调查结果，阐明稀土暴露与健康的关系。.