基于功能磁共振影像学的运动反馈脑网络研究

The kinetic feedback is an effective treatment of motor dysfunction, however, its brain mechanism remains unclear, and the treatment still lacks the related theoretical guidance and reference in clinical applications. Recently, the clinical researches have found that the rehabilitation of motor function was associated with the brain functional networks, thus, this proposal aims to examine brain functional networks of the kinetic feedback and further explore the related brain mechanism through experiments and data analysis methods of functional magnetic resonance imaging. On the aspect of experiment investigation, it will employ the regular and fast scanning methods of functional magnetic resonance imaging to design and perform series experiments of the kinetic feedback. On the aspect of data analysis, it will use the methods of independent component analysis and graph theory to identify functional networks of the kinetic feedback, determine the related spatial patterns, examine their functional interactions and analyze the relationship between motor performance and the functional interactions. These studies will help to reveal the brain mechanism of the kinetic feedback at the level of functional networks, and may provide new ideas for the treatment of kinetic feedback, promoting its related researches and applications in clinical practice.

运动反馈是运动功能障碍康复治疗的一种有效手段，然而其相关的脑机制还远不够清楚，反馈治疗在临床应用中仍缺乏相应的理论指导和依据。近年来，临床研究发现运动功能障碍的康复与脑功能网络及其功能交互属性息息相关，因此，本项目将结合功能磁共振影像实验和数据分析的方法，考察运动反馈的脑功能网络，探索运动反馈的脑机制。在实验研究方面，借助常规和快速功能磁共振扫描方法，设计、开展运动反馈的系列实验；在数据分析方面，采用独立成分分析和图论分析方法，刻画运动反馈的脑功能网络，确定网络的空间模式，考察网络功能交互属性，并进一步分析运动行为与网络功能交互属性之间的关系。这些工作将有助于在功能网络层面揭示运动反馈的脑机制，并有望为运动反馈治疗提供新的思路，推动其在临床实践中的研究与应用。

本项目基于功能磁共振影像学的方法，对运动反馈的脑机制展开了一系列研究。（1）刻画了运动反馈过程所涉及的脑功能网络空间模式，揭示了脑网络通过网络间功能连接的变化来响应不同的反馈条件（真反馈/假反馈）；（2）初步探索了运动反馈行为与脑活动之间的关系，揭示了基底神经节活动与反馈行为之间的关系，即基底神经节的低频（<0.01Hz）振幅与反馈过程中手指力度显著相关。（3）发现了“持续操作”与“组块交替”两种反馈模式下脑网络间连接的差异，观测到反馈过程可能存在相互独立的脑控制系统。项目的研究成果将为运动反馈的临床应用提供理论指导和依据。