仿生纳米陶瓷人工骨选择性激光烧结制备理论与生物活性研究

Due to the toxic side effects, poor biocompatibility, poor corrosion resistance and poor wear resistance of traditional metal artificial bone material, as well as the problems of non-customization, slow degradation and poor mechanical properties of non-metal artificial bone material, this project puts forward a personalized nano-coating bionic artificial bone manufacturing method which is based on the bionic modeling method，and the bone can made of nano ceramic, collagen and polymer composite materials. Firstly apply the image fusion、multimodal medical image analysis and reverse engineering method to establish the personalized bionic artificial bone three-dimensional model.Secondly based on the thermodynamic theory to study the changing rule of the microstructure of sintered samples and the artificial bone microstructure changes when materials in different ratio condition. Then the optimum parameters for artificial bone forming will be determined.Thirdly based on nano-laser energy and selective sintering technique, the nanometer ceramics artificial bone forming experiment will be performed to make nanometer ceramic bionic artificial bones.Finally discover the nano-coating manufacturing theory of nano ceramic bone, and based on this theory to develop the implantable nano-coating bionic artificial ceramic bone with excellent biocompatibility.Our research has important clinical and scientific research significance.will be determined.Based on nano-laser energy and selective sintering technique, the nanometer ceramics artificial bone forming experiment will be performed to make nanometer ceramic bionic artificial bones.Finally discover the nano-coating manufacturing theory of nano ceramic bone, and based on this theory to develop the implantable nano-coating bionic artificial ceramic bone with excellent biocompatibility.Our research has important clinical and scientific research significance.

针对传统金属人工骨材料具有毒副作用，生物相容性、抗腐蚀性和耐磨性较差，非金属人工骨成形的非定制化、降解速度缓慢、机械性能差等问题，本项目采用仿生建模方法研究个性化仿生纳米陶瓷/胶原/高分子复合材料人工骨的制备理论。首先采用图像融合，多模态医学影像分析和逆向工程技术相结合的方法，建立个性化具有微细多孔结构的仿生人工骨模型。然后基于热力学理论，研究不同激光能量密度下烧结样微结构的变化规律，不同材料配比情况下人工骨微结构变化情况，进而确定人工骨成形的最优化参数；以微米光斑的激光为能量，以选择性烧结为工艺途径，进行纳米陶瓷人工骨成形试验，研制纳米陶瓷仿生人工骨；揭示纳米陶瓷人工骨复合纳米涂层成形机理，在理论研究的基础上研发出具有优良生物相容性的可植入纳米陶瓷仿生纳米涂层人工骨，该方法具有重要的临床和科学研究意义。

本项目依托3D打印技术在生物医学领域的独特优势，针对传统骨修复材料的的缺陷，提出采用仿生建模方法研究个性化仿生纳米陶瓷/胶原/高分子复合材料人工骨的制备理论。本研究基于CT和MRI医学影像数据，建立个性化仿生人工骨模型，并用于手术指导，减少了手术时间，提高了手术精度；采用选择性激光烧结技术制备纳米陶瓷人工骨支架，通过分析纳米陶瓷人工骨的微观结构及烧结性能的关联规律，明确成形温度、激光功率、扫描速度、人工骨机械性能、表面形态之间的相互影响规律；在体外分子生物学实验中明确纳米陶瓷人工骨具有促进骨细胞分化与增殖的作用，证明了该人工骨具有良好的生物活性与生物相容性。此外团队积极开展新领域的应用探索，在生物陶瓷3D打印，人工骨材料等领域取得重要突破。依托本项目，共发表论文7篇，其中SCI文章6篇。申请专利一项，培养硕士研究生6名。此外，依托本项目的资助，项目负责人成功申请了硕士生导师的资格。