羽毛角蛋白基功能高分子的制备与构效关系

Using waste feathers and discarded feather products as raw materials, the feather keratin with uniform molecular weight is extracted in high yield rate. The obtained keratin is modified by chemical or physical method, which afforded repeated dissolvable keratin. Restriction enzyme cutting technology was also applied to prepare polypeptide of keratin. The extracted and modified keratin is applied to prepare the new medical polymer materials, such as keratin-based polymer microspheres, film and hydrogel, which show controlled release behaviors. The composition and structure of obtained feather keratin, polypeptide of keratin and their derivative will be characterized by instrument analysis method. The relationship between the structure and performance of keratin-based polymer will be investigated. Based on the development of environmental friendly polymer, the purpose of this project is for protecting ecological environment and realizing recycle of natural resource. Based on understanding the composition and structure characteristics of feather keratin, its application region will be largely expanded. It is also used to explore the recycle way of discarded natural polymers, especially polymer protein materials, and provide the theory basis for preparation of new biodegradable and biocompatibility medical polymer.

以废弃羽毛及废弃的羽毛制品为原料，高产率地提取分子量均一的羽毛角蛋白；通过化学、物理方法对提取的角蛋白进行改性后使其重复可溶，进一步采用酶切法将角蛋白剪切为能够用于分子组装的角蛋白片段；将提取的优质角蛋白用于制备具有可控释放功能的角蛋白膜、角蛋白基高分子微球、角蛋白基水凝胶等新型医用高分子材料。结合现代仪器分析方法研究羽毛角蛋白、多肽片段基改性产物的组成与结构，研究其结构与性能之间的关系。本项目立足环境友好高分子的发展前沿，以保护人类生态环境、实现资源充分利用为目的，通过对羽毛角蛋白组成与结构特点的清晰认识，拓展其应用范围。探索天然废弃高分子蛋白质材料的回收再利用途径，并为制备一类可降解的生物相容新型医用高分子材料提供理论依据。

本项目立足环境友好高分子的发展前沿，以保护人类生态环境、实现资源充分利用为目的，通过对羽毛角蛋白组成与结构特点的清晰认识，拓展其应用范围。首先，以废弃羽毛为原料，高产率地提取分子量均一的羽毛角蛋白；通过对提取的角蛋白进行改性，使其重复可溶。其次，将提取的优质角蛋白用于制备具有可控释放功能的角蛋白基医用高分子材料，考察最佳制备条件，进一步研究了其在不同条件下的释放性能。第三，采用红外光谱、热分析、扫描电镜、透射电镜等现代仪器分析方法，研究羽毛角蛋白及其高分子改性产物的组成与结构，研究其结构与性能之间的关系。宗旨，本项目探索了天然废弃高分子蛋白质材料的回收再利用途径，并为制备一类可降解的生物相容新型医用高分子材料提供基础。