基于三维共价有机骨架的气相色谱固定相研究

The development of novel stationary phases is of great significance in chromatography. Covalent organic frameworks (COFs) are a type of crystalline porous materials with highly ordered structures solely constructed from organic building units via strong covalent bonds. The unique properties of COFs make them potential application in diverse fields. However, the application of three-dimensional (3D) COFs as the stationary phases for gas chromatography (GC) has not been reported so far. Hence, the aim of this project is to fabricate 3D COFs and their capillary columns, to develop novel 3D COFs stationary phases for GC, to explore the application potential of 3D COFs in GC. This project is of great importance for enriching stationary phases for GC, opening new application of 3D COFs and developing novel capillary GC methods.

新颖固定相研究一直是色谱领域的重要课题。共价有机骨架（COFs）是一类有机单体通过共价键连接而成的新型晶体多孔有机聚合物，其独特的结构和性能使其在多个领域中展现出良好的应用前景。然而,目前未见有将三维COFs用作气相色谱固定相的报道。本项目拟采用微波合成等方法制备稳定的三维COFs，以制备的三维COFs作为气相色谱固定相，通过溶胶-凝胶等方法制备三维COFs毛细管气相色谱柱，考察三维COFs固定相的分离性能，研究其分离机理，发展基于三维COFs的新型气相色谱固定相，揭示三维COFs在气相色谱分离领域的应用潜力。本项目对于促进三维COFs的发展，丰富气相色谱固定相种类以及发展高效毛细管气相色谱分离新方法具有重要意义。

本项目发展了系列基于新型三维/二维共价有机骨架（3D/2D COF）色谱分离和固相萃取新方法。以第一作者或通讯作者在Angew. Chem. Int. Edit.、Chem. Commun.、J. Mater. Chem. A和J. Hazard. Mater. 等本领域主流期刊上发表SCI论文9篇，授权专利3项，获2020年高等学校科学研究优秀成果奖（科学技术）自然科学二等奖（3/7）和2019年中国分析测试协会自然科学奖（CAIA）特等奖（3/5）各一项。