基于苗医药特色理论与适应性数据挖掘技术的苗医方剂释理技术研究暨苗医特色方剂学理论框架构建

There are still no characteristic techniques and methods of explain composition principle which based on the theory of Miao medicine at present, makes "medical theory-diagnosis and treatment" and "efficacy-prescription" become relatively independent two plates.Now, interpret Miao medicine prescription, or simply list the efficacy of medicine, or mechanical copying the Chinese prescription theory of formula principle.It lack of the theoretical thinking of Miao medicine prescriptiongs in clinical application and new drug research of Miao, and have't the interpretation of how to compatibility drugs even been absurd expliain, lost the real support of features Miao medical prescription..Therefore, this study will be based on the characteristic theory of Miao medicine which has been basically established.We will focus on the multi-zone, a large sample of directional investigate and survey in the points of Miao medical prescription mechanism and principles. In the pilot study stage, lead into computer Data Mining Technology, carry out experimental studies of knowledge discovery related by proprietary techniques and methods of explain composition of Miao medicine principle, investigate-survey data and the public literature information for the data source,to find composing prescriptions mechanism for the purpose of Miao medical prescription,research establishment of the mass literature information Database Model, Data Mining algorithm and implementation, programming and information systems development.To completed the data mining of empirical material,to achieve knowledge discovery on the immanent logical relationship of "medical theory-property of a medicine-pesticide effect-principles of formulating prescription use pharmacy" of Miao medicine.Based on the objective knowledge discovery on the empirical data,we hope delve into the characteristic techniques and methods of explain composition principle in the frame of the theory of Miao medicine.Then we will be carry out applied research in some Miao medicine prescriptions and make up a Miao medicine prescriptiongs Systum. The achievement should establish pharmacology of traditional Miao medical formulae, provide academic guide to new drug research of Miao medicine and clinical application.

目前尚无基于苗医药理论的苗医特色方剂释理技术，苗医药"医理-诊疗"与"苗药功效-组方"两个理论板块相对割裂，目前阐释苗医方，或简单罗列单味药物功效，或机械套用中医方剂理论。临床应用苗药方剂及苗药创制缺少苗医药理论思维，无苗医配伍用药机理阐释甚则加以谬解，失却特色苗医方剂支撑之"实"。.故此，本研究拟基于苗医药特色理论，重点开展多区域、大样本的关于苗医方组方机理及原则的指向性问题调研；引入计算机数据挖掘技术，开展苗医方释理技术相关知识发现的实验研究，以调研资料和文献信息为数据来源，以发现苗医方组方用药机理为目的，建立海量文献信息数据挖掘的模式数据库，进行数据挖掘算法研究与实现、程序编制与信息系统开发，完成实证数据挖掘，实现苗医方"理-性-效-药-方"内在逻辑关系的客观知识发现。创建苗医方剂特色释理技术，应用释方技术构建苗医特色方剂学，为苗药新药研究、产业发展及苗医方临床运用提供理论指导。

“基于苗医药特色理论与适应性数据挖掘技术的苗医方剂释理技术研究暨苗医特色方剂学理论框架构建”是在苗医药挖掘研究基础上，针对苗族医方阐释无法套用中医方剂“君臣佐使”理论的现实，以苗医药特色理论为指导，利用数据挖掘技术，以期探究苗医方组方规律而确立的研究。通过对调研资料及文献中苗医方的分类建库，数据清理，统计分析，数据挖掘等手段，证明苗族医方配伍确有不同于中医方剂的独特性，是基于苗族医药哲学体系，以“开路药为先导（出现频次多与药量重），攻邪药为组方主体（药味多且总药量大），以泄浊药和补体药为辅”的苗医组方规律的假说确实普遍存在于各类病证所用医方中，但因部分苗族医方以单方、小验方形式存在，相对较为简略，该配伍规律并非在每一首苗族医方中均有体现。通过本研究目前所取得的初步研究结果，一方面为建立并完善苗医方剂理论体系奠定了基础，使苗医方剂研究得到了学界认同并获得了延伸项目贵州省科技基金重大课题及贵州苗医药研究重大专项子课题共两项；另一方面为阐释现有苗药成方制剂组方的独特性提供了可能，将起到完善苗族医药理论体系的重要作用；同时对今后开展苗医药现代研究进行组方具有指导意义。