本课题立足中医理论,遵循"塞因塞用"的中医治疗法则,借鉴并提炼古代艾灸治疗"肺痿"、"肺胀"的方法和经验,以博莱霉素气管灌注形成大鼠肺纤维化模型,艾灸"肺俞"、"膏肓俞"后,运用电镜、放免、免疫组化、RT-PCR、蛋白芯片技术对其肺纤维化程度以及肺组织TGF-β信号通路相关信号分子进行检测,深入探讨艾灸抑制肺纤维化的作用机制,以期揭示艾灸治疗肺纤维化的信号传导关键环节,为艾灸治疗肺纤维化的临床运用提供依据,将针灸作用原理研究进一步向前推进。
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数据更新时间:2023-05-31
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