小鼠腭裂相关新基因功能的研究
基本信息
结项摘要
腭裂是最常见的先天性畸形之一，其发生机制尚不清楚，这为腭裂的防治工作带来困难。申请者利用差异消减杂交技术筛选到一批腭裂相关基因，并发现6条未知基因。对这些未知基因功能的研究可能为其发病机制的阐明提供理论基础。故本研究首先采用原位杂交和real time PCR技术在腭突发育的不同时间点对新基因在腭突中的表达部位和表达量的变化进行动态研究。然后在此基础上选取基因采用RNAi技术来研究这些基因在腭突发
项目摘要
项目成果
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数据更新时间：2023-05-31
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