以核酸为作用靶的内源性生物活性物质的研究
基本信息
结项摘要
A series of modified nucleosides were synthesized and their anticancer activities.were investigated. It was found that 8-chloroadenosine showed the growth.inhibition on different cancer cells..2. Isonucleosides were synthesized from D-, L-xylose and D-glucose.Oligonucleotides containing isonucleoside can form the double helix with the complementary DNA and RNA and exhibited the stability against to Rnase..3. 17 papers have been published and one Chinese patent, two scientific awards are.awarded in 1997 and 1999
按计划完成了本课题的要求1.研究了环核苷酸的结构修饰及其生物活性,发现有抗癌活性的核苷类化合物S-氯腺苷目前已进入临床试验2.合成了4种结构的异核苷类化合物并把这些异核甘掺入寡核苷酸结构中研究了它们的稳定和杂交性质发现了所有这些杂有异核苷的寡泉核苷酸都有抗核酸确的性质而杂交性质随结构而异发现结构中有附加羟其可以啬 加杂交稳定性3.找到了几种抚HBV的三种形成寡泉核苷酸和及义寡核苷成及几种的抑制肿瘤生长和转利的反义寡核苷酸4.发现了单磷化寡核苷成的修伟为法比硫代磷酸修伟 稳定性更好本项研究先发表论文 26篇其中国际501收杂志14篇获得中国专种,一项申请5项获国家教育科技进步奖,二项培养类后4人博士生7人硕士生一个.
项目摘要
项目成果
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数据更新时间：2023-05-31
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