V型特种光纤特性及其生物传感应用研究

Fiber-optic sensors are widely used in the field of biosensors because of their non-destructive characteristic. The common optical fiber biosensors, such as long period grating (LPFG), titled fiber Bragg grating (TFBG), D-shape fiber, tapered fiber, have such problems as complicated manufacturing process, poor repeatability and limited detection range. In this project, a special optical fiber with open V-groove channel is proposed. The characteristics of V-groove fiber are related to its structural parameters and sensitive to the external environment. The test substance can be easily placed in the opened V-groove channel, which is useful for immune protein molecules, cancer cells, DNA and other biological testing. This project plans to design and fabricate V-groove special optical fiber, to explore the manufacturing technology of V-groove special optical fiber, and to study the characteristics of V-groove special optical fiber. Based on these, a V-groove fiber based biological testing platform is designed and set up, and the application in biological detection is emphasized. This project will deeply integrate the special optical fiber sensing technology and the biological testing field and develop new biological testing platform based on V-groove special optical fiber, which is expected to provide a new way for biological testing.

光纤传感器由于其非破坏性的特点而广泛的应用于生物传感领域。目前常见的基于长周期光纤光栅、倾斜光纤光栅、D型光纤、锥形光纤的光纤生物传感器存在制作工艺复杂、重复性较差、检测范围有限等问题。本项目提出了一种具有开放V型通道的特种光纤，其特性与其结构参数直接相关，对外界环境敏感，开放V型通道可以方便的放入待测物质，可应用于免疫蛋白分子检测、肿瘤细胞检测、DNA检测等生物检测领域。项目拟设计并制备V型特种光纤，探索V型特种光纤的制备工艺，研究V型特种光纤的特性，在此基础上搭建基于V型特种光纤的生物检测平台，重点研究V型特种光纤在生物检测中的应用。项目的开展将深度融合特种光纤传感技术和生物检测领域，开发基于V型特种光纤的生物检测平台，有望为生物检测提供一种新途径。

光纤传感器具有重要的实用价值和广阔的应用前景。在各种类型的光纤传感器中，折射率传感器由于其在新兴的生化和医学应用方面的巨大潜力而受到了广泛的关注。目前常见的基于长周期光纤光栅、倾斜光纤光栅、D型光纤、锥形光纤的光纤生物传感器存在制作工艺复杂、重复性较差、检测范围有限等问题。本项目提出了一种具有开放V型通道的特种光纤，其特性与其结构参数直接相关，对外界环境敏感，开放V型通道可以方便的与外界进行交互，是一种极佳的折射率传感器件。项目探索了V型特种光纤的制备工艺，设计并制备了3种不同参数的V型特种光纤，重点研究了V型特种光纤的模式特性及传感特性，提出并实现了nL级微量液体的折射率传感，为搭建基于V型特种光纤的生物检测平台奠定了理论基础和实验基础，有望为生物检测提供一种新途径。