口腔正畸治疗引起的患者面部外观变化预测研究

The original intention of many malocclusion patients for orthodontic treatment was to improve their facial appearance. However, there is no such computer-aided orthodontic treatment method and system which was developed for improving patients’ facial appearance. Clinical orthodontic treatment is mainly conducted to correct patients’ dentition, and how the facial appearance will change to be after the treatment is uncontrollable. As a result, patients are often not satisfied with the treatment results regarding the facial appearance change. For the purpose of implementing the orthodontic treatment with controllable tooth movement and facial appearance change, this project proposes to develop a prediction method for facial appearance change induced by tooth movement to provide reference for orthodontic treatment planning. The three-dimensional models of teeth and maxillofacial soft/hard tissue will be reconstructed based on multi-source image fusion. The deformation of facial soft tissue induced by tooth movement will be simulated based on biomechanical simulation analysis, then the facial appearance after treatment will be predicted. To verify and modify the prediction method, the prediction and reference models of facial appearance after treatment will be reconstructed from images of patients captured before and after orthodontic treatment. The implementation of this project will provide a computer-aided method and tool for the orthodontic treatment with predictable and controllable facial appearance change, and would have important promotion action for improving the orthodontic treatment results and enhancing doctor-patient communication. It has great social significance and potential application value considering the tens of millions of patients.

改善面部外观是众多错颌畸形患者进行正畸治疗的初衷。然而，国内外尚缺少以改善患者面部外观为目标的正畸辅助治疗方法和系统；临床正畸治疗主要矫正患者牙颌，对患者面部外观变化结果不可控，难以达到患者改善面部外观的预期。为此，本项目提出研究建立牙齿移动引起的面部外观变化预测方法，为正畸治疗方案优化提供参考，以实现牙颌及面部外观变化均可控的正畸治疗。本项目拟基于多源图像融合重构患者牙齿及颌面软硬组织三维模型；基于生物力学仿真方法模拟牙齿移动引起的面部软组织形变，并预测治疗后的面部外观；根据患者治疗前后的图像建立面部软组织预测模型与参考模型，验证和改进面部外观变化预测方法。本项目的实施将为患者面部外观变化可预测可控的临床正畸治疗提供辅助方法和工具，对提高治疗效果、增强医患沟通有重要促进作用。研究结果面向数千万错颌畸形患者，具有重要的社会意义和潜在的应用价值。

改善面部外观是众多错颌畸形患者进行正畸治疗的初衷。然而，国内外尚缺少以改善患者面部外观为目标的正畸辅助治疗方法和系统；临床正畸治疗主要矫正患者牙颌，对患者面部外观变化结果不可控，难以达到患者改善面部外观的预期。本项目以研究建立牙齿移动引起的颌面部形变预测方法为目标，为正畸治疗方案优化提供参考，以实现牙颌及面部外观变化均可控的正畸治疗。所完成的研究内容主要有：（1）建立了基于多源图像融合的口腔正畸治疗患者牙齿及颌面软硬组织三维模型重构方法；（2）建立了基于有限元生物力学模型的口腔正畸治疗牙齿移动引起的颌面部软组织形变预测方法，实现了口腔正畸治疗颌面部软组织形变的预测；（3）利用口腔正畸治疗患者治疗前后的图像建立了面部软组织预测模型与参考模型，对所建立的颌面部软组织形变预测方法进行了测试和验证。本项目共发表学术论文9篇，其中SCI国际期刊论文5篇、EI期刊/会议论文2篇；申请发明专利2项，其中国际PCT专利1项、国内发明专利1项；培养了研究生3名。本项目将为患者面部外观变化可预测可控的临床正畸治疗提供辅助方法和工具，对提高治疗效果、增强医患沟通有重要促进作用。研究结果面向数千万错颌畸形患者，具有重要的社会意义和潜在的经济价值。