新型99mTc/188Re肿瘤放射性药物的制备及肿瘤多药耐药基因显像剂的研究
基本信息
结项摘要
在参考有关文献和前期工作基础上，制备系列新型零价的[99mTcN]/188ReN -DTC单配配合物以及正一价阳离子的[99mTcN/188ReN(PNP)(DTC)]+混配配合物和99mTc(CO)3/188Re(CO)3－DTC配合物，通过改变氨荒酸盐配体(DTC)结构、配合物的中心核以及配合物的电荷，进行不同配合物性质对比研究以探求新型性能优良的99mTc/188Re肿瘤放射性药物。同时通过制备含有甲氧基的各种99mTc标记可视作P-gp转运底物的抗肿瘤药物来寻找性能优良的99mTc标记P-gp功能显像剂以用于检测肿瘤多药耐药。本项目研究成功将会直接推动具有自主知识产权的新型肿瘤放射性药物的发展进程，具有重要的科学研究价值。
项目摘要
项目成果
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数据更新时间：2023-05-31
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