有机磷毒害物化学发光分析研究

Organophosphorus toxicants, such as pesticides, have broad applications; however, their chemiluminescent studies have seldom been reported. The project is planning to systematically investigate the chemiluminescence of organophosphorus toxicants including nerve agent simulants, develop the chemiluminescence-enhancing approaches by nanomaterials-based catalysis and plasmonic effects, reveal chemiluminescent mechanisms and rules, and establish sensitive direct chemiluminescent methods for organophosphorus toxicants. Also, the project is planning to develop organophosphorus toxicant chemiluminescent aptasensors as well as to design and synthesize new chemiluminescent luminophores whose chemiluminescent properties will be much changed upon enzymolysis to construct organophosphorus toxicant chemiluminescent enzymatic biosensors. The project will promote the development of new chemiluminescent systems of organophosphorus compounds, deepen the understanding of the chemiluminescence of organophosphorus compounds, and popularize the application of chemiluminescent methods in organophosphorus compounds analysis. This project will also promote the development of clinically-important chemiluminescent detection methods for cholinesterase activity. It is of great significance to ensure public health and security.

有机磷毒害物如农药等应用广泛，但其化学发光研究偏少。本项目拟系统开展有机磷毒害物（包括神经毒剂模拟物）化学发光研究，探索基于纳米材料催化和等离子体增强效应提高化学发光效率的途径，揭示化学发光机理和规律，建立灵敏的有机磷毒害物直接化学发光分析新方法；设计合成经胆碱酯酶酶解后化学发光性质会发生显著变化的试剂并将之用于构建有机磷毒害物酶传感器；研制有机磷毒害物化学发光适配体传感器等。该申请项目的研究将促进发展有机磷化合物化学发光新体系，深化对有机磷化合物化学发光的认识，推动化学发光在有机磷化合物分析中的应用；也将促进具有重要临床价值的胆碱酯酶活性化学发光分析方法的发展；对保障人民健康和公共安全具有重要的意义。

有机磷毒害物如农药等应用广泛，但其化学发光研究偏少。本项目主要开展有机磷毒害物化学发光研究，发展了系列化学发光新体系包括电化学发光新体系，揭示化学发光机理，建立多种有机磷毒害物化学发光分析方法，研制了三种新型的成本低廉的化学发光装置。累计在Accounts of Chemical Research、Anal. Chem.和eScience等发表论文发表论文48篇。申请专利2项。受邀在巴基斯坦和乌兹别克斯坦各作大会报告1次，在第72届 Annual Meeting of the International Society of Electrochemistry、第241届ECS Meeting、2019 Workshop on New Nanostructured Materials and Biomaterials for Renewable Electrical Energy Sources和第十四届全国电分析化学学术会议作邀请报告 4 次。该研究促进了有机磷毒害物化学发光研究的发展，对保障人民健康和公共安全具有较重要的意义。