氧化石墨烯/光敏剂复合纳米材料的自组装、高效光动力治疗及机理研究

Graphene oxide, as a new carbon material, exhibits many novel and excellent performances and unique nanostructures, which become the research focus of scientists at different countries in recent years. Photodynamic therapy, based on the interaction of light, photosensitizer and oxygen, are a kind of new non-invasive treatments of cancer/non-cancer diseases. The present project is aimed to prepare some series of graphene oxide composite nanomaterials as drug carriers of photosensitizer, to explore the contribution and influence of variety of factors in orderly assembly process, and to reveal the relationships between structure and nature of the assembly unit, micro/nanostructures and photosensitizer composite. At the same time, present researches focus on the self-assembly process of the composites as drug carriers for photosensitizers and properties/mechanisms of photodynamic therapy in some biological systems. In the study, large-scale preparation technology and the dosage design should be also finally explored, in order to build sensitive and efficient high-selective drug of photodynamic therapy. Novel self-assembly and the mechanism of photodynamic therapy based on graphene oxide-photosensitizer composite drugs would broaden the research fields of graphene composites nanomaterials, construct novel photodynamic therapy drugs based on ordered graphene assembly, showing important significance and potential applications in the fields of the chemicals, pharmacochemistry, and materials science.

氧化石墨烯，作为新型碳质材料表现出许多奇特而优异的性能和独特的纳米结构，成为近年来国内外科学家关注研究的焦点。光动力疗法是以光、光敏剂和氧的相互作用为基础的一种新的非侵入性治疗癌症/非癌症疾病的手段。本项目拟制备若干作为光敏剂药物载体的氧化石墨烯复合纳米材料，探索多种因素在有序组装过程中的贡献和影响，揭示组装单元的结构与性质、微纳米的结构及担载光敏剂之间的构效关系。同时重点研究复合材料作为药物载体对若干光敏剂的自组装过程以及生物体系中光动力治疗性能及机理研究，摸索剂型设计及规模化制备技术，构建灵敏高效选择性好的新型光动力治疗药物。新型高效光敏剂药物载体氧化石墨烯复合材料的自组装、光动力治疗及机理研究，将拓展石墨烯复合材料的研究领域，构建基于石墨烯有序组装体的新型光动力治疗药物，对化学、医药、材料等领域相关研究工作具有重要的科学意义和潜在的应用价值。

光动力疗法是以光、光敏剂和氧的相互作用为基础的一种新的非侵入性治疗癌症/非癌症疾病的手段。氧化石墨烯，作为新型碳质材料表现出许多奇特而优异的性能和独特的纳米结构，成为近年来国内外科学家关注研究的焦点。我们严格按照研究计划开展研究工作，研究若干氧化石墨烯组装单元/光敏剂药物、复合水凝胶、多肽组装体的多层次有序组装与调控，构建功能有序组装体，重点研究这些有序组装结构作为新型PDT药物对生物体系中肿瘤/疾病细胞的光动力治疗性能及机理，构建灵敏高效选择性好的新型光动力治疗药物，从而为化学、生化工程、医药、材料等领域相关研究工作提供重要的理论基础和技术支持。特别是我们通过自组装的方法所开发的可注射、可自愈型胶原蛋白水凝胶为药物输送和组织工程等生物医学应用领域，提供了新的替代运载工具，具有良好的发展机遇和广泛的前景。该工作发表在期刊Advanced Materials，论文发表后受到国内外学者的广泛关注与兴趣，截止2018年底web of science 达到近200次引用，为ESI高被引论文和热点论文。围绕以上研究内容，本课题研究期间共发表论文80余篇，其中SCI收录论文70余篇，出版学术专著5章节，获河北省自然科学奖三等奖1项，授权发明专利1项，参加国内相关学术会议10余次，顺利完成预定研究计划和目标。