新型改性单体/锂基微晶玻璃填料牙科复合树脂的研制与性能研究

In order to solve the problem of polymerization shrinkage of dental composite resin and poor mechanical performance that is difficult to meet the clinical requirements, we design novel resin monomers three trifluoromethyl phenyl acrylate prepared glycidylester ( Bis-TFM-GMA ). The intermediates of new monomer three trifluoromethyl phenyl epoxy resin have been prepared as the basis of this project; biphenyl structure of Bis-TFM-GMA not only can reduce the change of spatial structure, but also can result smaller polymerization shrinkage, while enhancing the rigidity which can improve wear resistance. In this project,we will synthesis new monomer of Bis-TFM-GMA and design different proportion of initiating systems; After lighte cured, the solidify depth will be tested, infrared spectroscopy (FT-IR) will be used to measured the change of functional monomers after polymerization of Bis-TFM-GMA. The effect of different proportion of initiating systems on the photosensitivity of Bis-TFM-GMA will be studyed.The experiment is to explore the possibility of the new monomer Bis-TFM-GMA as dental composite resin organic matrix, and aiming at laying the foundation for the development of new low polymerization shrinkage of dental composite resin.

针对牙科复合树脂充填材料聚合收缩率大、力学性能难以满足临床要求等问题，设计新型树脂单体三氟甲基苯基型丙烯酸酯缩水甘油酯（Bis-TFM-GMA），以所制备的新型单体的中间体三氟甲基苯基型环氧树脂为基础，期望利用Bis-TFM-GMA的联苯结构,达到既能降低聚合时的空间结构变化，减小收缩，同时可以增强树脂的刚性，提高其耐磨性的目的；实验拟合成新型单体Bis-TFM-GMA，设计不同配比的引发体系；光照聚合固化后测试其固化深度；采用红外光谱（FT-IR）测定聚合后单体官能团的变化；研究新型单体对不同配比引发体系的光敏性，探讨新型单体Bis-TFM-GMA作为牙科复合树脂有机基质的可能性，为研制新型低聚合收缩牙科树脂奠定基础。

针对现有牙科复合树脂材料机械强度低,承受咀嚼压力易碎裂,聚合固化过程中易出现聚合收缩,形成微渗漏等关键科学问题,本项目拟设计合成了新型改性树脂基质单体3,3′,5,5′—四甲基联苯二酚丙烯酸缩水甘油酯（TMBP-GA）。通过核磁共振谱仪（1H-NMR）和傅立叶红外光谱（FTIR）对新型单体的结构进行了表征，采用红外分析计算单体聚合的双键转化率，万能实验机测试固化树脂材料的机械性能，并与双酚A双甲基丙烯酸缩水甘油酯（Bis-GMA）聚合形成的树脂进行了对比;探讨了TMBP-GA树脂单体与稀释剂TEGDMA、光引发剂樟脑醌（CQ）和助引发剂DMAEMA形成树脂固化体系后，是否能在可见光固化灯光照后形成有效的固化；研究了TMBP-GA树脂单体的联苯结构是否能够改善树脂的机械性能。研究发现TMBP-GA树脂单体固化体系在光照60s后能够固化形成TMBP-GA树脂，双键转化率与Bis-GMA树脂无统计学差异；TMBP-GA树脂的挠曲强度显著高于Bis - GMA树脂；聚合收缩率显著小于Bis-GMA树脂。本研究采用树脂基质联苯结构替代Bis-GMA单体分子中的双酚A结构，新型TMBP-GA树脂单体能够实现有效固化，并能够改善树脂基质部分的机械性能，减小聚合收缩，对于解决牙科复合树脂的临床应用问题奠定了基础。通过本研究，提供了一种新型牙科复合树脂基质单体。