交变电磁场下磁纳米颗粒产热分布的电磁探测方法研究

Quantitatively obtain of the distribution of the magnetic nanoparticles heat caused by alternating electromagnetic field can not only reveal the mechanism of heat magnetic nanoparticles, but also one of the current challenges of magnetic nanoparticles based cancer hyperthermia facing, but there is yet no non-invasive for obtaining the heat distribution method. Our previous study demonstrated a nonlinear magnetization response magnetic nanoparticles can obtain concentration distribution of magnetic nanoparticles, in preliminary experiments, we found through simulation, in the presence of an applied gradient field, non-saturation magnetization of the magnetic nanoparticles there exists an approximately linear relationship between the response of the 3rd and 5th order harmonic ratio and temperature. We therefore believe that, by applying a selecting gradient field space we can get the temperature distribution of the magnetic nanoparticles. Based on magnetic nanoparticles magnetization Response Spectrum platform and add selection gradient field, by moving through space sample, this proposal intends to use electromagnetic information to detect magnetic nanoparticles heat distribution, and further reveal the relationship between several factors,like the external alternating electromagnetic field amplitude and frequency, concentration of magnetic nanoparticles, and magnetic nanoparticles heat distribution. This study will provide a new theoretical and technical support for tumor magnetic hyperthermia non-invasive temperature monitoring and selection of magnetic nanoparticles.

获取在交变电磁场下人体内深部磁纳米颗粒的产热分布是基于磁纳米颗粒的肿瘤靶向磁热疗目前所面临的难题之一，然而目前尚无一种能够非介入式的直接获取磁纳米颗粒温度分布的方法。我们前期通过理论分析与仿真发现，在外加梯度场存在的情况下，未被饱和的磁纳米颗粒磁化响应的第3和第5阶谐波之比和温度之间存在着近似线性关系。因此，我们认为，通过外加空间选择梯度场我们能够获取磁纳米颗粒的温度分布。本课题拟在磁纳米颗粒磁化响应波谱平台基础上，添加空间选择梯度场，通过样品的空间移动，利用电磁信息来探测磁纳米颗粒的产热分布，并进一步揭示外加交变电磁场的幅度和频率、磁纳米颗粒的浓度分布等各种相关参数对于磁纳米颗粒产热分布的影响。该研究将为肿瘤磁热疗所需的无损温度监测及磁纳米颗粒制备提供新的理论及技术支持。

获取在交变电磁场下人体内深部磁纳米颗粒的产热分布是基于磁纳米颗粒的肿瘤靶向磁热疗目前所面临的难题之一，然而目前尚无一种能够非介入式的直接获取磁纳米颗粒温度分布的方法。我们前期通过理论分析与仿真发现，在外加梯度场存在的情况下，未被饱和的磁纳米颗 粒磁化响应的第3和第5阶谐波之比和温度之间存在着近似线性关系。因此，我们认为通过外加空间选择梯度场我们能够获取磁纳米颗粒的温度分布。本课题在磁纳米颗粒磁化响应波谱平台基础上，设计并制作了空间选择梯度场，通过样品的空间移动，利用电磁信息来探测磁纳米颗粒的 产热分布，并进一步揭示外加交变电磁场的幅度和频率等各种相关参数对于磁纳米颗粒产热分布的影响。该研究将为肿瘤磁热疗所需的无损温度监测及磁纳米颗粒制备提供新的理论及技术支持。