具有诊疗一体化的多模靶向MOFs新探针的制备及其影像学评价

Nanoscale Metal-organic frameworks (MOFs) as a class of novel crystalline materials have attracted much attention recently. They have been shown to be a sort of promising in-vivo anticancer agent, as their distinctive advantages such as high porosity, surface area, readily synthesized, and structure controllable etc. We developed a kind of novel nanoparticles Au@Fe-BDC, for the purpose of the targeted delivery of anticancer therapeutics and multimodal contrast agents. Based on the behavior of Au and Fe-BDC particles in optics and magnetics, we utilized the optical imaging, the photoacoustic imaging and the magnetic resonance imaging for the tumor research. In this proposal, we wish to improve the efficiency of tumor diagnosis and to avoid the “false-positive” diagnosis, hence to provide an accuracy diagnosis in early cancer stages. According to the MOFs’ drug loading behaviors, it will increase the specificity and potency during the oncotherapy, but also decease the toxic side effect to the normal tissue. In summary, MOFs will be a prospective integrated probe in the early cancer diagnosis and timely treatment.

金属有机框架材料(MOFs)是近年来研究的新型热门材料，由于其具有孔隙率高，比表面积大，合成方便，骨架规模大小结构可控，配体与金属可替换，以及可根据目标要求作化学修饰等优点，将MOFs设计成诊疗一体化探针有很大的应用前景。设计MOFs材料具有靶向性、包埋抗癌药物的造影探针Au@Fe-BDC，通过Au以及Fe-BDC的光学、磁学行为，利用光声成像、核磁成像等多种手段探究肿瘤成像行为，并通过包埋的药物缓释提高治疗效果，最终达到在诊断的过程中同时进行治疗。本项目旨在利用MOFs探针的造影行为，提高肿瘤诊断效率，避免“假阳性”诊断结果，为肿瘤早期精确诊断提供依据；研究MOFs探针的载药行为，提高对肿瘤治疗的选择特异性、药效性，降低对正常组织的毒副作用，这将为恶性肿瘤的早期诊断、及时治疗提供具有高特异性、高灵敏度的一种新型诊疗一体化探针。

本项目通过设计修饰和改造金属有机框架材料(MOFs)，提高MOFs材料的靶向效果和成像效果，利用光声成像、核磁成像等多种手段探究肿瘤成像行为；通过医学手术切除的问题，设计了手术切除探针，实现在成像信号引导下的肿瘤精准切除；通过热疗这种新辅助治疗的加入，在成像引导下进行肿瘤的治疗，进而提高治疗效果，最终达到在诊断的过程中同时进行治疗。本项目设计合成的分子探针提高了肿瘤诊断效率，避免“假阳性”诊断结果，为肿瘤早期精确诊断提供依据；治疗效果提高对肿瘤治疗的选择特异性，降低对正常组织的毒副作用，这将为恶性肿瘤的早期诊断、及时治疗提供具有高特异性、高灵敏度的一种新型诊疗一体化探针。