一个新型抗癌化合物对急性骨髓性白血病细胞Sin3A复合体的作用
基本信息
结项摘要
Sin3A是表观遗传学的核心分子之一,在基因调控方面起着非常关键的作用。为了克服传统维生素甲酸的局限，我们以传统的维甲酸结构作参考，合成了一系列新型化合物。其中3-Cl-AHPC是最有效而毒性又很低的抗癌化合物。我们发现3-Cl-AHPC与传统的维生素甲酸受体没有多少亲合力。它结合到Sin3A上，是迄今为止发现的第一个结合到Sin3A复合体上的化合物。我们新发现3-Cl-AHPC能引起两个未知蛋白质p52、p38和已知蛋白HSP90、HDAC4与Sin3A的结合。本课题主要是以3-Cl-AHPC为工具, 研究p52、p38、HSP90和HDAC4在急性骨髓性白血病细胞Sin3A复合体中的作用。我们拟观察这些蛋白质对Sin3A复合体的HDAC活性, 及Sin3A复合体相关靶基因的影响。
项目摘要
项目成果
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数据更新时间：2023-05-31
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