离子传感微流控芯片的制备及水质分析应用

Several aspects will be considered further in this project for improving the analytical performance of all-solid-state ion selective electrode. Microfluidic ionic analysis chips with good performance and low cost will be fabricated and applied in our life. The improvement of all solid state ion selective electrode sensors includes: (1) Preparation and optimization of solid contact ion-to-electron transducer with good performance for enhancing the stability and reproducibility of the all-solid-state ion selective electrodes. (2) In order to maintian consistency, ITO and polydimethyl siloxane (PDMS) microfluidic chips will be made in the laboratory through photo lithography-etching procedure. To improve the reproducibility of sensors, electrode modification will be made by special equipment. A stable and effective all-solid-state reference electrode will be also fabricated. Novel all-solid-state ion selective microfluidic chips will be produced. (3) Based on the research mentioned above, the resulting all-solid-state ion selective microfluidic chips will be used in multi-channel test and flow detection of drinking water, further portable detection of soil fertilizer and real time detection of electrolyte ions in human body.

针对全固态离子选择性电极存在的若干问题，有目的采取不同的手段和技术进行改进和解决，制备低成本、高性能、微型化的离子传感芯片，推进全固态离子选择性电极在实际测量中的应用。主要工作包括以下几个方面：（1）研发、优化、筛选高性能、易操作的离子-电子信号转换层材料，有效增强所构建的离子传感微流控芯片的电位信号输出稳定性和重现性；（2）采用光刻-腐蚀方法制作微流控芯片，保证电极的一致性；使用点样机制备离子传感膜，减少人为操作引起的误差，保证离子传感器的平行性；研究长期稳定且有效的全固态参比电极的制备方法，最终开发新型离子传感微流控芯片；（3）采用上述的离子传感微流控芯片实现饮用水分析包括不同离子的同时检测和同一离子的跟踪实时监测，将其应用扩展到土壤中氮磷钾等离子的便携式检测甚至人体中电解质离子的实时监测等。

本项目主要目标制备了低成本、高性能、微型化的离子传感芯片，推进了全固态离子选择性电极在实际测量中的应用。主要完成工作包括：（1）研发、优化、筛选高性能、易操作的离子-电子信号转换层材料，主要包括金纳米簇和疏水碳基纳米材料用于构建的高灵敏度和稳定性离子传感器；（2）采用喷涂、光刻等方法制作纸基及玻璃离子芯片，制备长期稳定且有效的全固态金参比电极，并开发相应的电位采集系统实现离子的测量；（3）采用上述的离子传感芯片实现了海水中K+、NH4+ 和NO3-的检测，所制备的纸基芯片具备一定的可穿戴性实现了人体汗液中不同K+、Na+、Cl-和H+同时检测和实时监测。（4）采用干法纺丝工艺制备了一种高拉伸性能的金纳米线浸渍苯乙烯/丁烯-苯乙烯纤维，制备了具有高拉伸性能的可穿戴Na+、Cl-和H+电位离子传感器。