RNA编辑影响miRNA形成和表达调控功能的研究
基本信息
结项摘要
miRNA和A至I RNA编辑属于双链RNA结构研究范畴，我们发现一些miRNA发生编辑，通过体外和体内RNA编辑实验I（次黄嘌呤）的TLC检测分析和克隆测序均证实了miRNA发生了 A至I编辑。在此基础上，通过生物信息学结合通过分子生物学技术，进一步研究miRNA前体的A至I RNA编辑特性，应用ADAR-/ADAR-小鼠细胞和ADAR过度表达技术，深入分析RNA编辑对miRNA的稳定性和成熟加工的影响，探明A至I RNA编辑影响miRNA的分子机制，分析RNA编辑对miRNA对沉默的靶基因的表达及相关性状的调控作用，对从新的层次阐明miRNA介导的基因调控网络具有重要意义。
项目摘要
项目成果
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数据更新时间：2023-05-31
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